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Helping 'good' gut bacteria and clearing out the 'bad,' all in one treatment

Helping 'good' gut bacteria and clearing out the 'bad,' all in one treatment
Graphical abstract. Credit: ACS Central Science (2023). DOI: 10.1021/acscentsci.3c00227

Probiotics can help maintain a healthy gut microbiome or restore populations of "good bacteria" after a heavy course of antibiotics. But now, they could also be used as an effective treatment strategy for certain intestinal diseases, such as Crohn's disease. Researchers reporting in ACS Central Science have developed a microgel delivery system for probiotics that keeps "good" bacteria safe while actively clearing out "bad" ones. In mice, the system treated intestinal inflammation without side effects.

In the , there's a delicate balance of bacterial populations. When this balance is disrupted, bad bacteria can take over the colon, causing it to swell, resulting in . Certain diseases, including and Crohn's disease, involve chronic colitis and currently require immunosuppressants to treat them. These drugs are expensive and non-specific, sometimes giving rise to .

An alternative strategy is to deliver beneficial bacteria, or probiotics, to help restore balance. But to reach the colon, a treatment must first pass through stomach acid, withstand being cleared out by the intestine, then fight for space alongside the numerous invading bacteria. Pairing probiotics with a could make this strategy feasible, though most current approaches simply protect the probiotics from digestion without affecting the microbes responsible for the condition. So, Zhenzhong Zhang, Junjie Liu, Jinjin Shi and colleagues wanted to combine probiotics with specialized microgel spheres that could not only protect the good bacteria, but also actively help clear out the bad.

To create their system, the researchers combined sodium alginate, tungsten and calcium-containing nanoparticles into small, spherical microgels, then coated them with beneficial, probiotic bacteria. The gels protected the bacteria as they made their way through the stomach and increased their retention time in the colon. Once there, calprotectin proteins—highly expressed during colitis—bound to the calcium and disassembled the gels, allowing the tungsten to escape. By displacing molybdenum in a key enzyme substrate of the bad bacterium Enterobacteriaceae, tungsten inhibited the microbe's growth while leaving the probiotics unaffected.

In experiments using a colitis mouse model, the system allowed probiotics to proliferate in the intestine without any side effects. Additionally, mice with the microgel spheres did not exhibit many of the hallmarks of colitis, such as shortened colons or damaged intestinal barriers, showing that the delivery system could be a viable treatment strategy. Though the researchers also want to prove its utility in more advanced preclinical models, they say that this work provides a new perspective into treatments using colonizing .

More information: Calcium Tungstate Microgel Enhances the Delivery and Colonization of Probiotics during Colitis via Intestinal Ecological Niche Occupancy, ACS Central Science (2023). DOI: 10.1021/acscentsci.3c00227

Journal information: ACS Central Science

Citation: Helping 'good' gut bacteria and clearing out the 'bad,' all in one treatment (2023, June 21) retrieved 28 November 2023 from
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