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Research describes methodology for use of digital health technologies in Parkinson's disease clinical trials

clinical trial
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With 10 million people living with Parkinson's worldwide, collaboration and data sharing are crucial for driving innovation in drug development for the fastest-growing degenerative neurological condition.

Research leaders at CHeT have joined forces with organizations and regulators through C-Path's Critical Path for Parkinson's (CPP) Consortium, a precompetitive public-private partnership. CPP aims to accelerate the regulatory endorsement of digital tools in Parkinson's through its Digital Drug Development Tools (3DT) initiative.

In June 2023, the Journal of Parkinson's Disease published two open access manuscripts, representing companion papers from this partnership that detail steps in conducting interviews of people with Parkinson's who participated in a clinical research study using smartphones. The manuscripts report on relevant symptoms in early Parkinson's and assess the relevance of digital measures from a smartphone application and smartwatch from the patient perspective.

The study was led by Jamie Adams, M.D., Associate Professor of Neurology and Associate Director of CheT at the University of Rochester and Jennifer Mammen, Ph.D., Assistant Professor at the University of Rhode Island, with support from CPP.

"This project pioneers a new path to efficiently advance tools aligned with the patient voice by engaging with early and often," said Diane Stephenson, Ph.D., CPP Executive Director. "C-Path remains committed to learning what matters most to people living with Parkinson's."

"These manuscripts describe a novel methodology that will help inform the use of digital health technologies in clinical trials for Parkinson's disease and support more objective and patient-centered measures. The goal is to enable efficient, data-driven, and patient-centric utilization of digital health technologies to speed therapeutic development," said Adams. "Sharing the results with the study participants and witnessing how this information helped them in new ways has been most rewarding."

John Crawford, a CPP advisor, Parkinson's advocate, and manuscript coauthor states, "Digital health technologies have the potential to significantly impact Parkinson's management and have already revolutionized clinical trial conduct. Their advancement expedites trials, enhances intelligence, reduces costs, and ultimately accelerates the delivery of new therapies and technologies to patients."

More information: Jennifer R. Mammen et al, Relative Meaningfulness and Impacts of Symptoms in People with Early-Stage Parkinson's Disease, Journal of Parkinson's Disease (2023). DOI: 10.3233/JPD-225068 Jennifer R.

Mammen et al, Mapping Relevance of Digital Measures to Meaningful Symptoms and Impacts in Early Parkinson's Disease, Journal of Parkinson's Disease (2023). DOI: 10.3233/JPD-225122

Journal information: Journal of Parkinson's Disease
Provided by Critical Path Institute (C-Path)
Citation: Research describes methodology for use of digital health technologies in Parkinson's disease clinical trials (2023, July 6) retrieved 19 May 2024 from
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