This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

proofread

Integrative analysis reveals metabolic switch in aging astrocytes

Integrative analysis reveals metabolic switch in aging astrocytes
KEGG pathway enrichment analysis of astrocyte differential hub genes suggests a metabolic switch from aerobic glycolysis to oxidative phosphorylation during aging. Credit: Aging (2023). DOI: 10.18632/aging.204663

A new research paper titled "Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses" has been published in Aging.

Dysregulated central-energy metabolism is a hallmark of brain aging. Supplying enough energy for neurotransmission relies on the neuron-astrocyte metabolic network. In their new study, researchers Alejandro Acevedo, Felipe Torres, Miguel Kiwi, Felipe Baeza-Lehnert, L. Felipe Barros, Dasfne Lee-Liu, and Christian González-Billault from Universidad de Chile, Cedenna, University of California, San Diego, Centro de Estudios Científicos (CECs), Geroscience Center for Brain Health and Metabolism (GERO), Universidad San Sebastián, and the Buck Institute for Research on Aging aimed to identify genes contributing to age-associated brain functional decline.

The researchers write, "[...] we formulated an approach to analyze the metabolic network by integrating flux, network structure and transcriptomic databases of neurotransmission and aging."

Their findings support that during brain aging:

  • The astrocyte undergoes a from aerobic glycolysis to , decreasing lactate supply to the neuron, while the neuron suffers intrinsic energetic deficit by downregulation of Krebs cycle genes, including mdh1 and mdh2 (Malate-Aspartate Shuttle);
  • Branched-chain amino acid degradation genes are downregulated, identifying dld as a central regulator;
  • Ketone body synthesis increases in the neuron, while the astrocyte increases their utilization, in line with neuronal energy deficit in favor of astrocytes.

"The genes identified here are valuable candidates for future studies to understand the molecular mechanisms of healthy brain aging and prevent brain age-associated failure using as a target," the researchers conclude.

More information: Alejandro Acevedo et al, Metabolic switch in the aging astrocyte supported via integrative approach comprising network and transcriptome analyses, Aging (2023). DOI: 10.18632/aging.204663

Provided by Impact Journals LLC
Citation: Integrative analysis reveals metabolic switch in aging astrocytes (2023, October 24) retrieved 4 March 2024 from https://medicalxpress.com/news/2023-10-analysis-reveals-metabolic-aging-astrocytes.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Bioengineers uncover lipid metabolic dynamics in Drosophila brain during aging

0 shares

Feedback to editors