This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

trusted source

proofread

Antibiotics administered to mothers during childbirth linked to autoimmune diseases in children

mother
Credit: CC0 Public Domain

Children whose mothers have received antibiotic treatment during childbirth are more likely to develop autoimmune diseases compared to their counterparts, according to a recent registry-based study published in the American Journal of Obstetrics and Gynecology and conducted at the University of Oulu, Finland, involving nearly 46,000 children.

The most common in children include type 1 diabetes, , and rheumatic diseases. However, the study found that administration of antibiotics during childbirth showed no association with allergic diseases or asthma in the child.

Antibiotic treatment given to mothers during delivery effectively prevents rare serious infections caused by Group B streptococcus in newborns, thereby reducing associated mortality. In Finland, antibiotics are administered to mothers during childbirth if Group B streptococcus is detected in the before delivery, and almost one in four women delivering vaginally receives .

The research findings play a crucial role in assessing the potential drawbacks of perinatal antibiotic use and investigating the underlying mechanisms of immune-related diseases. Previous knowledge indicated that antibiotics given to mothers during childbirth affect the development of the child's intestinal microbiota. The study supports the idea that a normal gut microbiota may have implications for a child's long-term health.

Sofia Ainonen, the lead author of the article and a doctoral researcher at the University of Oulu states, "This is an that does not directly establish a cause-and-effect relationship between the antibiotics given to mothers during childbirth and the child's later health. The result is a statistical association possibly influenced by other factors as well."

According to Professor Terhi Ruuska, who led the study, the findings encourage the development of precise prevention methods for Group B streptococcus infections. One potential method could be a vaccine administered to mothers that does not impact the child's normal microbiota.

The study followed children born vaginally in Oulu University Hospital (OYS) and Oulaskangas hospital in Northern Ostrobothnia, Finland, between 2007 and 2018. The study utilized national registers from the National Institute for Health and Welfare, the Social Insurance Institution of Finland (Kela) and Statistics Finland, as well as high-quality electronic patient records from the hospitals in the OYS region, which provided comprehensive information on maternal antibiotic exposure.

More information: Sofia AINONEN et al, Risk of Immune-related Diseases in Childhood after Intrapartum Antibiotic Exposure, American Journal of Obstetrics and Gynecology (2024). DOI: 10.1016/j.ajog.2024.02.020

Provided by University of Oulu
Citation: Antibiotics administered to mothers during childbirth linked to autoimmune diseases in children (2024, February 22) retrieved 23 April 2024 from https://medicalxpress.com/news/2024-02-antibiotics-mothers-childbirth-linked-autoimmune.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Antibiotic use during pregnancy linked to childhood asthma

0 shares

Feedback to editors