This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

peer-reviewed publication

proofread

Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma

Evaluation of ruxolitinib, a Janus Kinase inhibitor, in multiple myeloma
Ruxolitinib exerts its anti-myeloma effects through several mechanisms. Credit: Oncotarget (2024). DOI: 10.18632/oncotarget.28547

A new research perspective titled "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma" has been published in Oncotarget.

In this new paper, researchers Ashley Del Dosso, Elizabeth Tadevosyan, and James R. Berenson from ONCOtherapeutics, Berenson Cancer Center, and Institute for Myeloma and Bone Cancer Research have discussed multiple myeloma (MM)—the most common primary malignancy of the bone marrow. No established curative treatment is currently available for patients diagnosed with MM.

In recent years, new and more effective drugs have become available for the treatment of this B-cell malignancy. These have often been evaluated together and in combination with older agents. However, even these novel combinations eventually become ineffective; and, thus, novel therapeutic approaches are necessary to help overcome resistance to these treatments.

Recently, the Janus Kinase (JAK) family of tyrosine kinases, specifically JAK1 and JAK2, has been shown to have a role in the pathogenesis of MM. Preclinical studies have demonstrated a role for JAK signaling in direct and indirect growth of MM and downregulation of anti-tumor immune responses in these patients.

Also, inhibition of JAK proteins enhances the anti-MM effects of other drugs used to treat MM. These findings have been confirmed in which have further demonstrated the and efficacy of JAK inhibition as a means to overcome resistance to currently available anti-MM therapies. Additional studies will provide further support for this promising new therapeutic approach for treating patients with MM.

The researchers note that "...sections of this article will be focused on studies of RUX [Ruxolitinib] in the preclinical and clinical settings focused on the treatment of relapsed/refractory (RR) MM."

More information: Ashley Del Dosso et al, Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma, Oncotarget (2024). DOI: 10.18632/oncotarget.28547

Journal information: Oncotarget
Provided by Impact Journals LLC
Citation: Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma (2024, February 7) retrieved 21 April 2024 from https://medicalxpress.com/news/2024-02-ruxolitinib-jak-inhibitor-multiple-myeloma.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers discover that blocking ephrin B2 signaling can stop multiple myeloma growth

1 shares

Feedback to editors