This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

trusted source

proofread

New device can treat injury from sepsis

blood
Credit: CC0 Public Domain

Prior to February 2024, limited therapeutics were available to treat sepsis, a life threatening organ dysfunction caused by a dysregulated host response to infection. Now, a new, commercially viable method of treatment is available to thousands of children with acute kidney injury who develop the often fatal condition.

Early diagnosis and treatment with antibiotics are currently the best approach to treating , but only two prior therapeutics have been FDA approved. Last month, the FDA approved the use of a therapeutic device invented and developed at the University of Michigan for use in children with and sepsis or a septic condition requiring continuous kidney replacement (dialysis with the artificial kidney) therapy in the intensive care unit.

The therapeutic device, called the selective cytopheretic device (SCD) or Quelimmune, is integrated into the blood circuit of the dialysis circuit used to treat patients with acute kidney failure. It can selectively calm the excessively activated white blood cells within the circulation, ameliorate tissue destruction, and has shown to reverse the course of sepsis to survival. Pooled analysis from two pediatric clinical trials was compelling, resulting in FDA approval for this treatment in with severe sepsis and multiorgan failure.

"Blood poisoning"

Sepsis is widely known as "blood poisoning" that can arise from any , triggering a cascading reaction of the body's host response to fight the infection. This response is driven by the circulating white blood cells.

The severity of sepsis is not due to the invading pathogen itself, but from the excessive activation of the white blood cells to fight the infection. If this activation is uncontrolled and prolonged, these cells begin to attack and destroy not only the pathogen but indiscriminately most tissues of the body. The heart, lungs, kidneys, liver can be damaged and, depending on the severity and time before treatment, multiple organs may fail.

"Sepsis starts as a local infection, but once it gets into the bloodstream, there's a even if the patient starts an antibiotic," said H. David Humes, MD, professor of nephrology and internal medicine.

"It's like a brushfire that becomes a forest fire, and it's very hard to stamp out."

White blood cells

Humes says that with technology available prior to the SCD, sepsis has a 50% mortality rate, even when treated in the best of circumstances. The SCD treats the primary cause of death from sepsis—the inflammatory system becoming excessive and unregulated. When this happens, the white blood cells begin to attack the tissues of the body, causing patients to have an unrelenting attack on their organs.

"Our technology focuses not on treating the bacteria, but treating this dysregulated immunologic system that is overreacting and destroying tissues within the body," Humes said. "That's the breakthrough with this technology."

Treatment with the SCD will be prescribed to children in intensive care. The device is attached to a pump system outside the body, which pumps blood through the device. The device captures the dysregulated white cells and through pharmacologic manipulation, calms the white cells and then releases them back to the circulation.

Sepsis is common, deadly

Nearly 2 million people and 75,000 children in the United States develop sepsis each year—greater than the number of individuals suffering from heart attacks or strokes. Sepsis kills 250,000 patients, including 7,000 children annually. The number of children dying from sepsis annually is greater than the number dying from all pediatric cancers combined, but providers are optimistic that technology like the SCD will increase the odds of patient survival.

"Sepsis causes lots of pain and difficulty for children in families, especially for patients too young to express themselves," Humes said. "That's why it's so critical that we have effective methods of treatment that target the root cause of the infection."

Citation: New device can treat injury from sepsis (2024, April 13) retrieved 27 May 2024 from https://medicalxpress.com/news/2024-04-device-injury-sepsis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Blood stem cells unlock clues for helping sepsis patients fight recurring infections

1 shares

Feedback to editors