Medications

New tricks for old antibiotics

Sepsis is estimated to cause 11 million deaths every year around the world. Its treatment is based on the use of antibiotics and organ support measures, but many times it fails due to unsuccessful attempts at modulating the ...

Diseases, Conditions, Syndromes

Online tool informs recovery prospects for sepsis survivors

The tool, available online, is the first of its kind and was developed and validated using anonymised data from around 120,000 sepsis patients from the ICNARC national database for critical care units across England.

Medications

Oral corticosteroid bursts carry risk for severe adverse events

(HealthDay)—Prescriptions for oral steroid bursts are associated with a 1.8- to 2.4-fold increased risk for severe adverse events within the first month after initiation of drug therapy, according to a study published online ...

Medications

Hormone involved in obesity is a risk factor for sepsis

A group of scientists from Instituto Gulbenkian de Ciência (IGC), led by Luís Moita, discovered that a hormone that has been pointed out as a treatment for obesity reduces the resistance to infection caused by bacteria ...

Immunology

Antihypotensive agent disrupts the immune system in sepsis

Patients who go into septic shock are treated with the antihypotensive agent norepinephrine. Researchers from Radboud University Medical Center published results in today's American Journal of Respiratory and Critical Care ...

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Sepsis

Sepsis is a serious medical condition characterized by a whole-body inflammatory state (called a systemic inflammatory response syndrome or SIRS) and the presence of a known or suspected infection. The body may develop this inflammatory response to microbes in the blood, urine, lungs, skin, or other tissues. An incorrect layman's term for sepsis is blood poisoning, more aptly applied to Septicemia, below.

Septicemia (also septicæmia [sep⋅ti⋅cæ⋅mi⋅a], or erroneously Septasemia and Septisema) is a related but deprecated (formerly sanctioned medical) term referring to the presence of pathogenic organisms in the blood-stream, leading to sepsis. The term has not been sharply defined. It has been inconsistently used in the past by medical professionals, for example as a synonym of bacteremia, causing some confusion. The present medical consensus is therefore that the term[which?] is problematic and should be avoided.

Sepsis is usually treated in the intensive care unit with intravenous fluids and antibiotics. If fluid replacement is insufficient to maintain blood pressure, specific vasopressor drugs can be used. Artificial ventilation and dialysis may be needed to support the function of the lungs and kidneys, respectively. To guide therapy, a central venous catheter and an arterial catheter may be placed. Sepsis patients require preventive measures for deep vein thrombosis, stress ulcers and pressure ulcers, unless other conditions prevent this. Some patients might benefit from tight control of blood sugar levels with insulin (targeting stress hyperglycemia), low-dose corticosteroids or activated drotrecogin alfa (recombinant protein C).

This text uses material from Wikipedia, licensed under CC BY-SA