Medications

IV vitamin C increases risk for death, organ failure in sepsis

For adults with sepsis who are receiving vasopressor therapy in the intensive care unit (ICU), intravenous vitamin C is associated with an increased risk for a composite of death or persistent organ dysfunction at 28 days, ...

Diseases, Conditions, Syndromes

Greater nurse staffing tied to better sepsis outcomes

Hospitals that provide more registered nurse hours of care could likely improve outcomes for Medicare beneficiaries with sepsis, according to a study published online May 27 in JAMA Health Forum.

Medications

Researchers develop IV injection treatment for sepsis

Purdue University researchers in the College of Pharmacy and College of Engineering are developing a patent-pending treatment that could impact millions of American lives each year.

Diseases, Conditions, Syndromes

New test predicts sepsis soon after infection

In a potential paradigm change for sepsis diagnostics, a new test predicted sepsis soon after infection in mice—well before blood clotting and organ failure—enabling early antibiotic treatment and markedly increased survival. ...

Medical research

Study: 'Good' cholesterol could help treat sepsis

Replenishing the body's high-density lipoprotein (HDL) could be an effective treatment for sepsis, according to a new University of Kentucky College of Medicine study published in Science Signaling.

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Sepsis

Sepsis is a serious medical condition characterized by a whole-body inflammatory state (called a systemic inflammatory response syndrome or SIRS) and the presence of a known or suspected infection. The body may develop this inflammatory response to microbes in the blood, urine, lungs, skin, or other tissues. An incorrect layman's term for sepsis is blood poisoning, more aptly applied to Septicemia, below.

Septicemia (also septicæmia [sep⋅ti⋅cæ⋅mi⋅a], or erroneously Septasemia and Septisema) is a related but deprecated (formerly sanctioned medical) term referring to the presence of pathogenic organisms in the blood-stream, leading to sepsis. The term has not been sharply defined. It has been inconsistently used in the past by medical professionals, for example as a synonym of bacteremia, causing some confusion. The present medical consensus is therefore that the term[which?] is problematic and should be avoided.

Sepsis is usually treated in the intensive care unit with intravenous fluids and antibiotics. If fluid replacement is insufficient to maintain blood pressure, specific vasopressor drugs can be used. Artificial ventilation and dialysis may be needed to support the function of the lungs and kidneys, respectively. To guide therapy, a central venous catheter and an arterial catheter may be placed. Sepsis patients require preventive measures for deep vein thrombosis, stress ulcers and pressure ulcers, unless other conditions prevent this. Some patients might benefit from tight control of blood sugar levels with insulin (targeting stress hyperglycemia), low-dose corticosteroids or activated drotrecogin alfa (recombinant protein C).

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