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Scientists harness ultrasound for drug delivery and tissue implantation

Technion scientists harness ultrasound for drug delivery and tissue implantation
Ultrasound mediated polymerization of acousto-sensitive biomaterials. Credit: Small Methods (2024). DOI: 10.1002/smtd.202301197

Research presents an advance in drug delivery and tissue implantation assisted by ultrasound, developed by researchers from the Technion Faculty of Biomedical Engineering. The work is published in the journal Small Methods.

Prof. Shulamit Levenberg's research group has developed an innovative non-invasive method for bio-printing and tissues deep within the body using external sound wave irradiation. The research team includes postdoctoral fellow Dr. Lior Debbi, who completed all of his academic degrees at the Technion, and Majd Machour, a doctoral student in the MD/Ph.D. program.

Many require precise delivery of biocompatible materials for various purposes such as localized drug release, grafting of tissues, and implantation of engineered cells and tissues for organ regeneration. Currently, highly invasive surgeries are the norm, and are accompanied by risks including infection, , and long healing periods.

In the researchers' innovative method, cells or drugs are delivered within a biological fluid ink directly to the treated area deep within the body through direct injection or catheterization. Subsequently, the engineered tissue is printed using sound waves emitted from an external ultrasonic transducer. Thus, engineered tissue can be built deep within the body without exposing the treated site.

The versatility of the new technology is demonstrated in contexts such as local cell transplantation, continuous localized over time, and three-dimensional bioprinting. The mechanical properties of the grafts can be tailored according to the target tissue and the desired rate.

More information: Lior Debbi et al, Ultrasound Mediated Polymerization for Cell Delivery, Drug Delivery, and 3D Printing, Small Methods (2024). DOI: 10.1002/smtd.202301197

Journal information: Small Methods
Citation: Scientists harness ultrasound for drug delivery and tissue implantation (2024, April 22) retrieved 16 June 2024 from
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