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Study finds GLP-1 receptor agonist use increases likelihood of antidepressant prescription

GLP-1 receptor agonist use increases likelihood of antidepressant prescription

Individuals taking glucagon-like peptide (GLP)-1 receptor agonists have a greater risk for subsequently being dispensed antidepressants, according to a study published online April 23 in Diabetes, Obesity, and Metabolism.

Osvaldo P. Almeida, Ph.D., from University of Notre Dame in Fremantle, Australia, and colleagues assessed whether dispensing of GLP-1 receptor agonists is associated with increased dispensing of . The analysis included a 10 percent random sample of the Australian Pharmaceutical Benefits Scheme data (2012 to 2022).

The researchers found that 358,075 of 1.7 million were dispensed antidepressants, and 8,495 of the 24,783 dispensed a GLP-1 receptor agonist were also dispensed an antidepressant in 2022 (odds ratio, 1.44).

Among 24,103 individuals dispensed a GLP-1 receptor agonist between 2012 and 2021, 8,083 were dispensed antidepressants in 2022 (odds ratio, 1.52). Among 1.2 million individuals who had not been dispensed antidepressants in 2012, there was a heightened risk for being dispensed an antidepressant between 2013 and 2022 following the dispensing of a GLP-1 receptor agonist (hazard ratio, 1.19).

"Individuals exposed to GLP-1 receptor agonists are at greater risk of being dispensed antidepressants," the authors write. "The possible impact of GLP-1 receptor agonists on the mood of consumers requires ongoing vigilance and further research."

More information: Osvaldo P. Almeida et al, Cross‐sectional, case‐control and longitudinal associations between exposure to glucagon‐like peptide‐1 receptor agonists and the dispensing of antidepressants, Diabetes, Obesity and Metabolism (2024). DOI: 10.1111/dom.15616

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Citation: Study finds GLP-1 receptor agonist use increases likelihood of antidepressant prescription (2024, May 16) retrieved 24 June 2024 from
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