A new study of inherited genetic risk indicates that common genetic variations throughout the genome act in addition to rare, deleterious mutations in autism-associated genes to create risk for autism.
May 16, 2017
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For almost a century, researchers have known that cancer cells have peculiar appetites, devouring glucose in ways that normal cells do not. But glucose uptake may tell only part of cancer's metabolic story. Researchers from ...
May 24, 2012
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Glioblastoma is an incurable brain cancer that kills most patients less than two years after diagnosis. The disease is difficult to treat largely because tumors each contain multiple kinds of cells. The aggressive brain cancer ...
Jul 19, 2019
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Physician-scientists at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute have discovered that a gene called FOXR2 that is normally turned off in most tissues in the body is activated in at least 70% ...
Jul 22, 2022
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It is estimated that one in three individuals of Ashkenazi Jewish (AJ) descent carry mutations that increase their risk for certain genetic diseases. For instance, Crohn's, a highly heritable inflammatory bowel disease, is ...
May 25, 2018
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Two research teams converge on epigenetic switches that feed treatment-resistant metastatic prostate tumors. This research highlights the value of exploring gene regulation and large-scale structural changes in the cancer ...
Jun 15, 2018
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Based on the largest resource of its kind, members of the Exome Aggregation Consortium (ExAC) led by scientists at the Broad Institute of MIT and Harvard report scientific findings from data on the exome sequences (protein-coding ...
Aug 18, 2016
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While mutations in protein-coding genes have held the limelight in cancer genomics, those in the noncoding genome (home to the regulatory elements that control gene activity) may also have powerful roles in driving tumor ...
Jun 29, 2017
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A team led by researchers at Broad Institute of MIT and Harvard, Dana-Farber Cancer Institute, and Harvard Medical School has developed a new method to identify thousands of DNA mutations accurately and efficiently in a patient's ...
Mar 18, 2022
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Sepsis is a dreaded, life-threatening condition that can occur when an infection spins out of control. Like a tsunami after an earthquake, sepsis occurs when an infection triggers a dysregulation of the immune system, which ...
Jun 9, 2021
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