A scientist at the Gladstone Institutes has identified how the lack of a brain chemical known as dopamine can rewire the interaction between two groups of brain cells and lead to symptoms of Parkinson's disease. This discovery ...
Sep 8, 2011
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For the roughly 1.5 million Americans per year who survive a traumatic brain injury, health outcomes vary widely. Not only can these injuries lead to a loss of coordination, depression, impulsivity, and difficulty concentrating, ...
Apr 19, 2024
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At the earliest stages of a new human life, cells that seem identical begin to divide into distinct types that eventually grow into a diverse array of tissues and organs. During this process, neighboring tissues exchange ...
Dec 2, 2021
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In the decade since the advent of CRISPR-Cas9 gene editing, researchers have used the technology to delete or change genes in a growing number of cell types. Now, researchers at Gladstone Institutes and UC San Francisco (UCSF) ...
May 11, 2021
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In the 40-some years since the beginning of the HIV/AIDS epidemic, scientists have learned a lot about the virus, the disease, and ways to treat it. But one thing they still don't completely understand is exactly which cells ...
Apr 27, 2021
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In people with central nervous system (CNS) lymphoma, cancerous B cells—a type of white blood cell—accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels. This disease is quite ...
Feb 17, 2021
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The latent reservoir is the last bastion of HIV's resistance to a cure. But it is difficult to destroy because it is invisible: the cells in the reservoir harbor virus that is dormant, so they don't have any viral proteins ...
Sep 30, 2020
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A team of Gladstone scientists and their partners at Xyphos Biosciences, Inc. describe a new way of attacking cells infected by HIV in this week's issue of the journal Cell. The work showcases a novel version of CAR-T, the ...
Oct 24, 2019
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January 2, 2019—As early as 3 months of age, infants with a severe form of epilepsy called Dravet syndrome start having convulsive seizures, during which their arms and legs jerk repeatedly. As they become toddlers, another ...
Jan 2, 2019
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Human papillomavirus (HPV) is widely known to cause nearly all cases of cervical cancer. However, you might not know that HPV also causes 70 percent of oropharyngeal cancer, a subset of head and neck cancers that affect the ...
Sep 12, 2018
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