All normal human tissues acquire mutations over time. Some of these mutations may be driver mutations that promote the development of cancer through increased proliferation and survival, while other mutations may be neutral ...
Aug 30, 2022
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Cells in the surrounding tumor microenvironment have a significant impact on cancer growth, survival and responses to therapy. Cancer-associated fibroblasts in the tumor environment have typically been associated with tumor ...
Aug 16, 2022
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143
Immune checkpoint inhibitors have revolutionized cancer care. The therapy works by preventing tumors from shutting down the immune response, which in turn allows T cells to kill cancer cells. Established checkpoint inhibitors ...
Jun 27, 2022
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Prostate cancer is the most common cancer among men in the United States. Many patients can live long lives due to early detection and treatment with androgen deprivation therapy. However, despite the benefits of this therapy, ...
Jun 15, 2022
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Alterations in metabolic processes are a hallmark of cancer and can lead to a tumor environment that is acidic. As a result, cancer cells must adapt to survive in this inhospitable environment. In a new study published in ...
May 10, 2022
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Most cancer treatments are based on using the maximum tolerated dose of a drug to kill as many cancer cells as possible. While this approach has led to patients achieving good responses to therapy, most patients develop drug ...
May 9, 2022
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61
Chimeric antigen receptor T-cell therapy, or CAR T, has made a big impact on the treatment of certain blood cancers, allowing patients with relapsed/refractory disease to live longer, healthier lives. But in clinical study, ...
May 5, 2022
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Ovarian cancer is a difficult to diagnose malignancy that is often caught at a more advanced stage. Treatments for this cancer have changed little over the past few decades, with surgery and chemotherapy being the most common ...
Apr 14, 2022
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Interactions between cells of the immune system and pre-cancerous cells are known to be important contributing factors to the initiation and progression of cancer. However, the dynamics of these interactions have not been ...
Apr 7, 2022
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93
Leptomeningeal disease is a rare complication of several different types of cancer, including melanoma. It occurs when tumor cells migrate to the cerebrospinal fluid and the tissue that surrounds the brain and spinal column ...
Mar 8, 2022
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