Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are a group of rare malignancies with overlapping features from myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) that include a variety of diseases ...
Jul 1, 2020
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There is a group of diseases whose symptoms have a common origin: a lesion in the endothelial tissue that covers the inside of the blood vessels. This lesion, called TMA (Thrombotic Microangiopathy), causes a migration of ...
Nov 8, 2019
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Immunotherapy has changed the way oncology patients are treated. Immunotherapy approaches, including the use of immunomodulatory agents to enhance anti-cancer responses and the recent development of adoptive cell therapies ...
Apr 21, 2022
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Researchers from the Epigenetics and Immune Disease Lab at the Josep Carreras Leukaemia Research Institute have recently shown that vitamin C improves the immunogenic properties of dendritic cells in vitro.
Nov 2, 2022
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Sonia Guil, leader of the Regulatory and Chromatin RNA group of Josep Carreras Leukemia Research Institute, and Lourdes Farré of ProCURE (Idibell) have discovered an intermediate molecule expressed from a region of the non-coding ...
Sep 4, 2019
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In the early 1980s, the first changes in DNA related to a chemical modification called methylation were discovered, followed by the discovery in the mid-1990s of the first tumor suppressor genes inactivated by these modifications ...
Dec 22, 2022
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Researchers of the Josep Carreras Leukaemia Research Institute discover that a leukaemic cell is capable of transforming into a non-cancerous cell through epigenetic changes.
Nov 13, 2019
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A team led by Dr. Manel Esteller, Director of the Josep Carreras Leukemia Research Institute, has improved the computational identification of potentially druggable gene amplifications in tumors, from epigenetic data. By ...
May 11, 2022
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Alterations in the chemical modifications that control gene expression, known as epigenetics, have proven to be one of the most characteristic properties of all human tumors. This realization has generated the development ...
Feb 5, 2024
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B-cell acute lymphoblastic leukemia (B-ALL) is characterized by the accumulation of abnormal immature B-cell precursors (BCP) in the bone marrow (BM), and is the most common pediatric cancer. Among the different subtypes ...
Apr 23, 2020
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