Medical research
Gene variant reduces cholesterol by two mechanisms
High levels of low-density lipoprotein (LDL) cholesterol increases the risk for coronary heart disease.
Jul 2, 2012
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Journal of Clinical Investigation
Oncology & Cancer
Doxorubicin-associated mitochondrial iron accumulation promotes cardiotoxicity
Doxorubicin is a widely used as a component of chemotherapy regimes; however, the use of doxorubicin is associated with severe cardiotoxicity. It is unclear exactly how doxorubicin promotes cardiotoxicity, but it has been ...
Jan 2, 2014
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Inflammatory disorders
Decreasing cancer risk associated with inflammatory bowel disease
Inflammatory bowel disease is caused by chronic inflammation , which leads to damage of the intestinal epithelium.
Jul 9, 2012
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Oncology & Cancer
Predicting nasopharyngeal carcinoma patient response to radiation therapy
Nasopharyngeal carcinoma (NPC) affects cells lining the nasopharynx. The majority of NPC cases can be cured by radiation therapy, however ~20% are resistant to radiation treatment.
Nov 25, 2013
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Genetics
Gene therapy-associated cancer incidence depends on vector design
National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping ...
Jan 20, 2015
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Oncology & Cancer
Cancerous cells from donor kidney linked to recipient skin cancer
Patients that receive kidney transplants have an increased risk of an invasive form of skin cancer. It is unclear if donor tissue contributes to cancer formation.
Aug 27, 2013
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Medical research
B and T cell-targeting drug ameliorates chronic graft-versus-host disease in mice
Hematopoietic stem cells (HSCs) can differentiate into all types of blood cells, including red blood cells and immune cells. While HSC transplantation can be life saving for patients with aggressive forms of blood cancer ...
Oct 1, 2014
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Neuroscience
Study indicates that the hippocampus mediates cognitive decline in Huntington's disease
Huntington's disease is a neurodegenerative disorder that results in involuntary spastic movement and loss control of voluntary motor function. Patients also exhibit a decline in cognitive ability. The defects in learning ...
Sep 2, 2014
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Oncology & Cancer
Marked for destruction: Newly developed compound triggers cancer cell death
The BCL-2 protein family plays a large role in determining whether cancer cells survive in response to therapy or undergo a form of cell death known as apoptosis. Cells are pressured toward apoptosis by expression of pro-apoptotic ...
May 24, 2012
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Medical research
Creating a new weapon in the fight against malaria
Over 200 million people contract malaria each year, and according to the World Health Organization, an estimated 655,000 people died from malaria in 2010.
May 8, 2012
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