Cancer has many faces—no wonder, then, that the range of cancer-causing mutations is huge as well. The totality of such genomic alterations in an individual is what experts call a "mutational landscape." These landscapes ...
Jan 25, 2023
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To perform coordinated movements, we rely on special sensory neurons in our muscles and joints. Without them, the brain wouldn't know what the rest of our body was doing. A team led by Niccolò Zampieri has studied their ...
Dec 9, 2022
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For decades, scientists in Berlin have been researching a strange hereditary condition that results in half the members of certain families having unusually short fingers and extremely high blood pressure. If left untreated, ...
Oct 19, 2022
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Every cell has two mechanisms for repairing DNA single- or double-strand breaks, which can be induced by such factors as environmental toxins, chemotherapy, or ionizing radiation. The first one consists of the DNA repair ...
Sep 21, 2022
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The exchange of gases between the air we breathe and our blood takes place via alveoli—tiny air sacs in our lungs. For this process to run smoothly, the epithelial cells of the alveoli produce a substance called "surfactant" ...
Sep 16, 2022
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134
A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery. The team found antibodies in the blood of malaria patients that had been ...
Aug 29, 2022
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111
Cardiomyopathy is not a uniform disease. Rather, individual genetic defects lead to heart failure in different ways, an international consortium reports in Science.
Aug 4, 2022
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For patients with lymphoma, multiple myeloma, or certain types of leukemia, treatment with chimeric antigen receptor T cells (CAR T cells) is sometimes the last chance of overcoming the cancer. The treatment involves taking ...
Jul 22, 2022
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307
Blood vessels must adapt their growth to the nutrients available in their surroundings so that they can keep organs adequately supplied. A team led by Michael Potente has identified two proteins that are important for this ...
Jun 20, 2022
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56
T cells are usually good at eliminating diseased cells, but they seem to fail when it comes to tumor cells. In JCI Insight, MDC teams led by Armin Rehm and Uta Höpken describe what inhibits this immune function, and how ...
Jun 13, 2022
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