Thomas Jefferson University

Medical research

New role for death molecule

Cellular death is vital for health. Without it, we could develop autoimmune diseases or cancers. But a cell's decision to self-destruct is tightly regulated, so that it only happens to serve the best interests of the body. ...

Diseases, Conditions, Syndromes

How fibrosis develops in butterfly syndrome patients

Children with a grave skin disorder known as butterfly syndrome develop severe and chronic blisters. Fibrosis, the thickening and scarring of connective tissues, is a major complication of the disease. Not only can fibrosis ...

Medical research

Blocking toxic-protein production in ALS

Patients with ALS frequently have a string of repeated DNA code in the cells of their brain, carrying hundreds to thousands of copies within the gene C9orf72. New research looks at what triggers these repeated sequences to ...

Cancer

'Christmas berry' plant compound could fight Uveal melanoma

Doctors diagnose about 2000 adults with uveal melanoma, a cancer of the eye, every year. In half of cases, the disease metastasizes to the liver. For these patients treatment options are scarce. Researchers at the Sidney ...

Cardiology

Treatment for underdiagnosed cause of debilitating chest pain

Patients who arrive at the hospital with heart-attack-like symptoms have had little recourse for their chest pain if scans came back clear, with no signs of blocked coronary arteries. Some of these cases are caused by a little-known ...

Cardiology

In heart failure, a stronger heart could spell worse symptoms

Heart failure patients fall into two general categories: those with weaker hearts, and those with stronger, but stiffer hearts that continue to eject the normal volume of blood with every beat. Although their hearts have ...

Cancer

How melanoma evades targeted therapies

Melanoma is the leading cause of death from skin cancer. Many patients develop metastatic disease that spreads to other parts of the body. One commonly used targeted therapy for metastatic melanomas works by attacking melanomas ...

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