A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, ...
Jul 22, 2021
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Cancer cells can develop resistance to therapy through both genetic and non-genetic mechanisms. But it is unclear how and why one of these routes to resistance prevails. Understanding this 'choice' by the cancer cells may ...
Jun 17, 2021
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Normal, non-cancerous liver tissue can act like tumor tissue when exposed to a diet high in fat, linking diet and obesity to the development of liver cancer. The Laboratory of Cellular Metabolism and Metabolic Regulation ...
Mar 10, 2021
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A team headed by Prof. Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology), in collaboration with Dr. Emanuele Berardi and Dr. Min Shang, revealed a new metabolic dialogue between inflammatory cells and muscle ...
Oct 29, 2020
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The brains of people living with Alzheimer's are riddled with plaques: protein aggregates consisting mainly of amyloid beta. Despite decades of research, the real contribution of these plaques to the disease process is still ...
Jul 22, 2020
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Whether white blood cells can be found in the brain has been controversial, and what they might be doing used to be a complete mystery. In a seminal study published in Cell, an international team of scientists led by Prof. ...
Jul 22, 2020
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With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before. In the latest edition of eLife, the team of Wim Annaert (VIB-KU Leuven) combines state-of-the-art imaging ...
Jul 9, 2020
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Two mutations identified in individuals with developmental and epileptic brain disease can be traced back to the same ion channel. Researchers have now elucidated how both independent mutations affect the channel's function: ...
Jun 18, 2020
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A collaborative study by research groups from the VIB-UGent Center for Inflammation Research and Ghent University uncovered a new mechanism causing colorectal cancer. The researchers found that abnormal expression of the ...
Jun 16, 2020
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Amyloids are particular protein assemblies with properties similar to silk, that serve numerous functions. They also form upon protein misfolding resulting in protein inactivation.
Jun 9, 2020
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