Oncology & Cancer

Finding new targets for acute myeloid leukemia in children

Acute myeloid leukemia (AML) is the second most common leukemia diagnosed in children. It is hard to treat and can be fatal in some cases. While there have been some recent successes with genetically targeted therapies for ...

Oncology & Cancer

Exploiting cancer's sweet tooth to develop a treatment

Inositol is a sugar required for cells to survive. Most cells either get it from the bloodstream or make it themselves. Since there is plenty of inositol available, some cancer cells decide to stop making it. Cold Spring ...

Oncology & Cancer

New risk factor identified for the most common childhood cancer

Acute lymphoblastic leukemia (ALL), a cancer involving white blood cells known as lymphocytes, is the most common childhood cancer, representing 25% of all cancer diagnoses. It's also one of the leading causes of childhood ...

Oncology & Cancer

Genomic markers of aggressive childhood leukemias identified

New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination. Over the course of a decade of work in several study sites ...

Oncology & Cancer

CRISPR screening tool identifies new drug target for leukemia

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn ...

Oncology & Cancer

Refining treatment for childhood leukemia

Scientists at St. Jude Children's Research Hospital are working with colleagues in China to develop better therapy for childhood acute lymphoblastic leukemia (ALL). Results from a large phase 3 noninferiority clinical trial ...

Medical research

Can leukemia in children with Down syndrome be prevented?

For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future.

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