Genetics

CRISPR enhances gene therapy to fight inherited diseases

Gene therapy has shown promise in treating inherited genetic diseases, but a major issue that has frustrated scientists remains: Replacing a "bad" gene with a healthy one often is a short-lived fix. Typically, the healthy ...

Diseases, Conditions, Syndromes

What is the virus that has killed 7 children in New Jersey?

(HealthDay)—New Jersey health officials on Wednesday confirmed the deaths of seven children following infection with an adenovirus—a member of the same viral family that causes the common cold.

Diseases, Conditions, Syndromes

WHO: 1 child has died in mystery liver disease outbreak

The World Health Organization says at least one death has been reported in connection with a mysterious liver disease outbreak affecting children in Europe and the United States.

Diseases, Conditions, Syndromes

Why the mystery hepatitis in children may have been here all along

The children typically show up at hospitals scattered across the country, one or two at a time, with symptoms like unexplained vomiting, diarrhea and jaundice. These are the classic signs of hepatitis—inflammation of the ...

Diseases, Conditions, Syndromes

Alabama cases of acute hepatitis in kids show link to viruses: CDC

The origins of a continuing outbreak of acute, potentially lethal hepatitis striking children in countries around the world has experts mystified. But a cluster of recent cases in Alabama all show ties to common viruses, ...

Diseases, Conditions, Syndromes

Using crystals to unpack how viruses work

Researchers at Cardiff University have used X-ray crystallography and computer simulation to get a closer look at how viruses bind cells and cause infection.

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Adenoviridae

Adenoviruses are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) icosahedral viruses composed of a nucleocapsid and a double-stranded linear DNA genome. There are 57 described serotypes in humans, which are responsible for 5–10% of upper respiratory infections in children, and many infections in adults as well.

Viruses of the family Adenoviridae infect various species of vertebrates, including humans. Adenoviruses were first isolated in 1953 from human adenoids. They are classified as group I under the Baltimore classification scheme, meaning their genomes consist of double stranded DNA.

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