For more than 100 years, researchers have been unable to explain why cancer cells contain abnormal numbers of chromosomes, a phenomenon known as aneuploidy. Many believed aneuploidy was simply a random byproduct of cancer.
Oct 31, 2013
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They are the Robinson Crusoes of the intracellular world -- lone chromosomes, whole and hardy, stranded outside the nucleus where their fellow chromosomes reside. Such castaways, each confined to its own "micronucleus," are ...
Jan 19, 2012
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People with an additional X or Y chromosome—a genetic condition known as supernumerary sex chromosome aneuploidy—have an increased risk of developing blood clots known as venous thromboembolism (VTE), a Geisinger study ...
Jan 25, 2023
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Patients with non-small cell lung cancer (NSCLC) whose cancer cells have low levels of aneuploidy—an abnormal number of chromosomes—tend to respond better to immune checkpoint inhibitor drugs than patients with higher ...
Apr 11, 2021
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Cancer remains the leading cause of death by disease in children and young people in the UK. It's a stark reminder of how much work remains to be done, and why Cancer Research UK (CRUK) is making pediatric cancer a priority. ...
Mar 18, 2021
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The presence of an abnormal number of chromosomes in the genetic profile of early-stage embryos may be far more common—and potentially less threatening—during normal human development than is currently appreciated, according ...
Jul 8, 2020
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A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal ...
Jun 17, 2013
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Cohesin is a ring-shaped protein complex involved in the spatial organization of the genome and in mitotic chromosome structure. Vertebrate somatic cells have two versions of cohesin that contain either SA1 or SA2, but their ...
May 3, 2012
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Washington State University researchers have confirmed a critical step in cell division that results in age-related miscarriages and birth defects, including Down syndrome.
Apr 14, 2011
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