The major obstacle to curing HIV is a vast reservoir of "latent, replication-competent proviruses," which have infiltrated the very cells that help orchestrate the immune response.
Some people diagnosed with HIV are able to eradicate the virus without antiretroviral medications or even stem cell transplants, possessing the ability to naturally suppress the virus and achieve a medically verifiable cure.
Researchers at MIT and Brigham and Women's Hospital have developed a capsule that can deliver a week's worth of HIV drugs in a single dose. This advance could make it much easier for patients to adhere to the strict schedule ...
Jan 9, 2018
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(Medical Xpress)—It's a good news/bad news scenario: Researchers have made a new discovery about HIV that will redirect curative strategies toward latent reservoirs of HIV—that's the good news. The bad news is that they ...
University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.
Mar 19, 2024
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Bacterial infections can lead to the formation of abscesses—pockets of dead cells and debris surrounded by inflammatory immune cells. Bacteria multiply within abscesses, causing more inflammation and further damage to surrounding ...
Jan 17, 2024
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An international study led by MELIS-UPF researchers from the Infection Biology and Molecular Virology laboratories has identified and characterized Schlafen 12 (SLFN 12) as a novel HIV restriction factor. SLFN 12 shuts down ...
May 10, 2023
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Understanding HIV latency at the molecular level is crucial for efforts to eliminate the viral scourge that causes AIDS. Latent infected cell reservoirs—where the human immunodeficiency virus (HIV) hides and persists in ...
Jan 10, 2023
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Dolutegravir-based antiretroviral therapies (ART) for HIV-1 are more effective for pregnant people than some other ART regimens commonly used in the U.S. and Europe, according to a study led by Harvard T.H. Chan School of ...
Aug 31, 2022
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Instead of relying on the cell's repair mechanisms, the vaccinia virus MacGyvers a tool for DNA repair from one that it already uses to copy DNA, reports a team of researchers at the Medical University of South Carolina (MUSC) ...
May 17, 2022
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