Half of melanoma patients with the BRAF mutation have a positive response to treatment with BRAF inhibitors, but nearly all of those patients develop resistance to the drugs and experience disease progression.
Feb 24, 2014
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Low pH in tumours counteracts the desired effect of the drug chloroquine, according to a new study from Karolinska Institutet in Sweden. The results, which are published in the journal Autophagy, might explain possible lack ...
Feb 11, 2014
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New findings from the team of Claudine Kraft at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna give insights into how cells dispose of their waste. Malfunctions in this ...
Jan 17, 2014
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(Medical Xpress)—Whitehead Institute researchers have determined that the lipid storage disorder Niemann-Pick type C1 (NPC1) disease is caused not only by defects in cholesterol processing but also in autophagy—a key ...
Jan 9, 2014
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Surprisingly little is known about schizophrenia. It was only recognized as a medical condition in the past few decades, and its exact causes remain unclear. Since there is no objective test for schizophrenia, its diagnosis ...
Dec 30, 2013
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Autophagy, a key cellular auto-cleaning mechanism, mediates the formation of amyloid beta plaques, one of the hallmarks of Alzheimer's disease. It might be a potential drug target for the treatment of the disease, concludes ...
Oct 3, 2013
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(Medical Xpress)—Researchers at the University of Virginia School of Medicine have identified an important new benefit of exercise: It increases the ability of skeletal muscle cells to remove damaged components and other ...
Sep 26, 2013
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A new study published in the prestigious PLoS One journal changes our understanding of the pathogenesis of age-related macular degeneration (AMD). The researchers found that degenerative changes and loss of vision are caused ...
Aug 21, 2013
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Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds ...
Aug 5, 2013
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Adding more color to your diet in the form of berries is encouraged by many nutrition experts. The protective effect of berries against inflammation has been documented in many studies. Diets supplemented with blueberries ...
Apr 21, 2013
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