Diseases, Conditions, Syndromes

Multiple sclerosis: Myelin may be detrimental to nerve fibers

Multiple sclerosis (MS) affects millions of people worldwide, and there is currently no cure for this disease of the central nervous system. Damage to the nerve fibers, also called axons, is responsible for the severity of ...

Genetics

Remnants of ancient virus may fuel ALS, says new research

More than 5,000 people are diagnosed annually with ALS (amyotrophic lateral sclerosis), a fatal, neurodegenerative disease that attacks nerve cells in the brain and spinal cord, gradually robbing people of the ability to ...

Neuroscience

Researchers create digital map of sympathetic nervous system

A team of UCF College of Medicine researchers has created a digital topographical map of the cardiac sympathetic neural network, the region that controls the body's heart rate and its "fight-or-flight" response. They hope ...

Neuroscience

Exploring the brain's 'magnificent wiring'

For a functioning brain to develop from its embryonic beginnings, so much has to happen and go exactly right with exquisite precision, according to a just-so sequence in space and time. It's like starting with a brick that ...

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Axon

An axon or nerve fiber is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neuron's cell body or soma.

An axon is one of two types of protoplasmic protrusions that extrude from the cell body of a neuron, the other type being dendrites. Axons are distinguished from dendrites by several features, including shape (dendrites often taper while axons usually maintain a constant radius), length (dendrites are restricted to a small region around the cell body while axons can be much longer), and function (dendrites usually receive signals while axons usually transmit them). All of these rules have exceptions, however.

Some types of neurons have no axon—these are called amacrine cells, and transmit signals from their dendrites. No neuron ever has more than one axon; however in invertebrates such as insects the axon sometimes consists of several regions that function more or less independently of each other. Most axons branch, in some cases very profusely.

Axons make contact with other cells—usually other neurons but sometimes muscle or gland cells—at junctions called synapses. At a synapse, the membrane of the axon closely adjoins the membrane of the target cell, and special molecular structures serve to transmit electrical or electrochemical signals across the gap. Some synaptic junctions appear partway along an axon as it extends—these are called en passant ("in passing") synapses. Other synapses appear as terminals at the ends of axonal branches. A single axon, with all its branches taken together, can innervate multiple parts of the brain and generate thousands of synaptic terminals.

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