Oncology & Cancer

Study links widely-used drug azathioprine to skin cancers

A drug used to treat inflammatory bowel disease, arthritis and vasculitis as well as to prevent organ rejection in transplant patients has been identified as an important contributor to skin cancer development, in a research ...

Diseases, Conditions, Syndromes

Methotrexate, azathioprine seem safe long-term for dermatitis

(HealthDay)—Methotrexate and azathioprine appear to be effective and safe as maintenance treatments in moderate-to-severe atopic dermatitis for up to five years, according to research published online Dec. 13 in the British ...

Diseases, Conditions, Syndromes

Immune suppressant ineffective in treating leprosy inflammation

Throughout the course of a leprosy infection, patients often have episodes of painful inflammation affecting their skin and nerves. Researchers have continuously struggled with finding effective drugs to treat these so-called ...

Diseases, Conditions, Syndromes

Meta-analysis compares tx for inducing remission in Crohn's

(HealthDay)—For adult patients with Crohn's disease, adalimumab and infliximab + azathioprine are most effective for induction and maintenance of remission, according to a meta-analysis published in the February issue of ...

Inflammatory disorders

Therapy for severe vasculitis shows long-term effectiveness

Administering the drug rituximab once weekly for one month provides the same benefits as 18 months of daily immunosuppressive therapy in people with severe forms of vasculitis, or inflammation of the blood vessels, a study ...

Diseases, Conditions, Syndromes

Drug-induced liver injury is on the rise

More people are being affected by drug-induced liver injury (DILI) than ever before, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association. This type of liver injury ...

Diseases, Conditions, Syndromes

Azathioprine may benefit pediatric atopic dermatitis

(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity seems useful for monitoring ...

Diseases, Conditions, Syndromes

Methotrexate and azathioprine equally efficacious for eczema

(HealthDay) -- Methotrexate and azathioprine may be equally effective in treating severe atopic eczema in adults, according to a critical appraisal of a study published in the April issue of the British Journal of Dermatology.

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Azathioprine (/ˌæzəˈθaɪɵpriːn/) is a purine analogue immunosuppressive drug. It is used to prevent organ rejection following organ transplantation and to treat a vast array of autoimmune diseases, including rheumatoid arthritis, pemphigus, inflammatory bowel disease (such as Crohn's disease and ulcerative Colitis), multiple sclerosis, autoimmune hepatitis, atopic dermatitis, Myasthenia Gravis, Neuromyelitis optica / NMO / Devic, restrictive lung disease, and others.

Azathioprine is produced by a number of generic manufacturers and as branded names (Azasan by Salix in the U.S., Imuran by GlaxoSmithKline in Canada,the U.S., Australia, Ireland and Great Britain, Azamun in Finland and Imurel in Scandinavia and France).

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