Diabetes

Novel findings explain indirect regulation of glucose homeostasis

The hormone secreting islets of Langerhans in the pancreas have a unique cyto-architecture that allows functional interrelationships between the different cell types. Somatostatin is secreted by the delta cell and is an effective ...

Alzheimer's disease & dementia

An alternate theory for what causes Alzheimer's disease

Alzheimer's disease, the most common cause of dementia among the elderly, is characterized by plaques and tangles in the brain, with most efforts at finding a cure focused on these abnormal structures. But a University of ...

Neuroscience

Tissue model reveals role of blood-brain barrier in Alzheimer's

Beta-amyloid plaques, the protein aggregates that form in the brains of Alzheimer's patients, disrupt many brain functions and can kill neurons. They can also damage the blood-brain barrier—the normally tight border that ...

Diabetes

New insight into the biology of insulin release

In a new study, Yale researchers challenge a long-held assumption about how insulin-producing cells in the pancreas sense and respond to glucose. Their findings could lead to changes in the way that scientists approach the ...

Medical research

Immunotherapy and diabetes—a game of hide and seek?

Immune checkpoint inhibitors (ICIs) are an emerging type of cancer immunotherapy that uses the immune system to attack cancer cells. However, in some patients they cause the immune system to attack healthy cells, leading ...

Diabetes

Drug delays type 1 diabetes in people at high risk

A treatment affecting the immune system effectively slowed the progression to clinical type 1 diabetes in high risk individuals, according to findings from National Institutes of Health-funded research. The study is the first ...

Medical research

Researchers restore beta-cell function by deleting old cells

Research from Joslin Diabetes Center has shown in mice that insulin resistance increases the proportion of aged beta-cells which are dysfunction. Such an increase in aged beta-cells could lead to type 2 diabetes. These researchers ...

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