Medications

Review of impact of drug holidays on bone health

The impact of interruption of anti-osteoporosis treatment in patients on therapy with bisphosphonates or denosumab is reviewed in a new International Osteoporosis Foundation (IOF) working group paper 'Fracture risk following ...

Diseases, Conditions, Syndromes

Many postmenopausal women do not receive treatment for osteoporosis

The benefits of treating osteoporosis in postmenopausal women outweigh the perceived risks, according to a Clinical Practice Guideline issued today by the Endocrine Society. The Society introduced the guideline during a news ...

Diseases, Conditions, Syndromes

Study sheds light on atypical periprosthetic femoral fractures

Following surgery, some patients experience a broken bone around the implants of a total hip replacement—called a periprosthetic femoral fracture. In a study of such patients published in the Journal of Bone and Mineral ...

Diseases, Conditions, Syndromes

Finding the right osteoporosis medication

Dear Mayo Clinic: The bisphosphonate drugs I take for osteoporosis aren't working in my case. My doctor has suggested a few alternatives. Any thoughts on what might be best?

Diseases, Conditions, Syndromes

Confusion about long-term treatment of osteoporosis clarified

Osteoporosis is a common disorder among postmenopausal women which results in an increased risk of fractures. While several therapies improve bone strength and reduce the risk of spine and hip fracture, there is no cure for ...

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Bisphosphonate

In pharmacology, bisphosphonates (also called diphosphonates) are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.

Bone has constant turnover, and is kept in balance (homeostasis) by osteoblasts creating bone and osteoclasts digesting bone. Bisphosphonates inhibit the digestion of bone by osteoclasts.

Osteoclasts also have constant turnover and normally destroy themselves by a process called cell suicide (apoptosis). Bisphosphonates encourage osteoclasts to undergo apoptosis.

The uses of bisphosphonates include the prevention and treatment of osteoporosis, osteitis deformans ("Paget's disease of bone"), bone metastasis (with or without hypercalcaemia), multiple myeloma, primary hyperparathyroidism, osteogenesis imperfecta and other conditions that feature bone fragility.

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