Oncology & Cancer

Five key medical advances related to bone marrow transplantation

In the six decades since blood and marrow transplantation was used to treat patients with blood cancers, this once experimental treatment has become a vital cancer-fighting tool. Mayo Clinic in Rochester, Minnesota, is celebrating ...

Oncology & Cancer

Study illuminates precancerous 'clonal outgrowth' in blood cells

A common, spontaneous mutation in blood stem cells, which has been linked to higher risks of blood cancer and cardiovascular disease, may promote these diseases by altering the stem cells' programming of gene activity and ...

Oncology & Cancer

How intestinal cancer stem cells evade anti-angiogenic therapy

A team led by Ludwig Lausanne's Tatiana Petrova, Jeremiah Bernier-Latmani and alum Christoph Cisarovsky identified a novel mechanism by which stem cells in intestinal tumors generate new blood vessels and evade anti-angiogenic ...

Oncology & Cancer

Cell therapy could improve bone marrow transplant safety

UCLA researchers report a step forward in the development of an "off-the-shelf" cell therapy that could reduce the severity of graft-versus-host disease in people receiving donor bone marrow transplants for the treatment ...

Neuroscience

Stem cell-gene therapy shows promise in ALS safety trial

Cedars-Sinai investigators have developed an investigational therapy using support cells and a protective protein that can be delivered past the blood-brain barrier. This combined stem cell and gene therapy can potentially ...

Cardiology

Treating, preventing heart attacks with human tissue models

A heart attack, or myocardial infarction, is one of the leading causes of mortality worldwide, resulting in 18 million deaths per year. These numbers are expected to increase in coming years because of cardiovascular complications ...

Gastroenterology

Optimization of human small intestinal organoids

Researchers from the Organoid group (formerly the Clevers group) have improved human small intestinal organoids—miniature versions of the small intestine. This will help them to better study the functioning of the small ...

Oncology & Cancer

Potential new treatment for angioimmunoblastic T-cell lymphoma

A type of blood cell cancer called angioimmunoblastic T-cell lymphoma (AITL) can develop as mutations accumulate with age in the stem cells from which the T cells in the blood develop. However, the underlying mechanism by ...

Medical research

Inflammation accelerates aging of the hematopoietic system

In mice, inflammation in early to mid-life leads to a permanent decline in functional blood stem cells, according to a recent publication by scientists from the German Cancer Research Center (DKFZ) and the Stem Cell Institute ...

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