Mutations of the alkaline phosphatase (ALPL) gene in the liver, bone and kidney can cause hypophosphatasia (HPP) and early-onset bone dysplasia, asserting its key role in human bone development. Despite its importance, its ...
A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.
Sep 27, 2023
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Aged bone marrow promotes the expansion of arterial smooth muscle cells and exacerbates the build-up of fatty deposits in artery walls, a new Yale study has found.
Feb 2, 2023
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As we age, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bone-marrow stem cells, ...
Sep 13, 2021
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High intensity physical activity in early life might help maximize peak hip strength and prevent osteoporosis in later life, according to a study from University of Bristol researchers published in JAMA Network Open today.
Aug 18, 2020
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Scientists have identified an unexpected player in the immune reaction gone awry that causes vision loss in patients with age-related macular degeneration (AMD), according to a new study published today in eLife.
May 5, 2020
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Leukaemia promotes premature ageing in healthy bone marrow cells—according to new research from the University of East Anglia.
Jan 30, 2019
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A handful of brain cells deep in the brain may play a surprising role in controlling women's bone density, according to new research by UC San Francisco and UCLA scientists.
Jan 11, 2019
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Inflammation is the common denominator of many chronic age-related diseases such as arthritis, gout, Alzheimer's, and diabetes. But according to a Yale School of Medicine study, even in the absence of a disease, inflammation ...
Oct 21, 2013
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In a recent study led by Uppsala University, the researchers compared the DNA of identical (monozygotic) twins of different age. They could show that structural modifications of the DNA, where large or small DNA segments ...
Feb 2, 2012
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