Medical research

For large bone injuries, it's Sonic hedgehog to the rescue

A USC Stem Cell study in npj Regenerative Medicine presents intriguing evidence that large bone injuries might trigger a repair strategy in adults that recapitulates elements of skeletal formation in utero. Key to this repair ...

Neuroscience

New insights on the importance of skull channels for brain health

Investigators led by a team at Massachusetts General Hospital (MGH) that previously discovered tiny channels in the skull have now found that cerebrospinal fluid (also known as "brain water") can exit the brain into the skull's ...

Surgery

New strategies for engineering stable articular cartilage

A new study assesses the effect of the gremlin-1 (GREM1) protein on the in vitro and in vivo stability of bone marrow stem cell (BMSC)-derived cartilage engineered within scaffolds. The study design and results are reported ...

Immunology

How one inflammatory disorder exacerbates another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, ...

Medical research

How it works: The protein that stimulates muscle growth

In the gym, you are not just pumping iron, you are oxygenating muscle cells which keeps those muscles healthy, strong and growing—a process called hypertrophy, or an increase in muscle mass due to an increase in muscle ...

Medical research

Breast cancer: Why metastasis spreads to the bone

When cancer cells break away from a primary tumor and migrate to other organs, this is called "metastatic cancer." The organs affected by these metastases, however, depend in part on their tissue of origin. In the case of ...

Genetics

Bioprinting for bone repair improved with gene therapy

Given enough time and energy, the body will heal, but when doctors or engineers intervene, the processes do not always proceed as planned because chemicals that control and facilitate the healing process are missing. Now, ...

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