Polygenic risk scores, which estimate a person's disease risk based on thousands or millions of common genetic variants, perform poorly in screening and prediction of common diseases such as heart disease, according to a ...
Oct 17, 2023
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The Ivy Brain Tumor Center at the Barrow Neurological Institute, has released the results of its recent Phase 0 clinical trial of the breast cancer drug ribociclib (Kisqali) for the treatment of recurrent glioblastoma. The ...
Jul 25, 2019
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The well-known drug tamoxifen could exploit a weakness in the physical 'scaffolds' around tumours, according to research led by Imperial.
Dec 11, 2018
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How TTP488 (azeliragon), an experimental drug, impairs aggressive, triple-negative breast cancer from metastasizing has been uncovered at the cellular level, according to researchers at Georgetown University's Lombardi Comprehensive ...
Jul 18, 2023
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Fanconi anemia is a recessive genetic disorder affecting 1 in 350,000 babies, which leaves cells unable to repair damaged DNA. This lack of repair puts Fanconi anemia patients at high risk for developing a variety of cancers, ...
Sep 4, 2012
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Up to 80% of breast cancer deaths occur in patients with tumors that express estrogen receptor-alpha. Although these estrogen receptor-positive (ER+) breast cancers often initially respond to standard treatment that combines ...
May 24, 2024
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Tagworks Pharmaceuticals, based at Radboud University Medical Center, has developed a new technique for the targeted delivery of chemotherapy for tumors in difficult cases. By way of controlled 'click-to-release' of the chemotherapy ...
May 4, 2018
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As cancer treatment gets more sophisticated, we need more refined drug delivery systems that can simultaneously deliver multiple drugs with different chemical makeups.
May 16, 2019
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A new discovery published online in The FASEB Journal promises to help physicians identify patients most likely to benefit from breast cancer drug therapies. If the compound, called "Nanobody," proves effective in clinical ...
Apr 11, 2011
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US health officials on Friday revoked the authorization of Roche's Avastin for breast cancer treatment, saying it concluded the drug had "not been shown to be safe and effective for that use."
Nov 18, 2011
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