A chimeric antigen receptor (CAR) T-cell therapy that targets the protein mesothelin showed no evidence of major toxicity and had antitumor activity in patients with malignant pleural disease from mesothelioma, according ...
Mar 31, 2019
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In an effort to further individualize therapy and avoid over-treating patients, researchers at the Johns Hopkins Kimmel Cancer Center report a new study using PET scans has identified a biomarker that may accurately predict ...
Feb 21, 2019
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A new "smart drug" has shown promise for women with metastatic triple-negative breast cancer, based on data from a clinical trial at NewYork-Presbyterian/Columbia's Herbert Irving Comprehensive Cancer Center and other centers. ...
Feb 20, 2019
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A study provides new insight into how the stiffening of breast tissue plays a role in breast cancer development. By examining how mammary cells respond in a stiffness-changing hydrogel, bioengineers at the University of California ...
Feb 13, 2019
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Researchers in Finland have discovered a drug combination that collaborates with the cancer cell oncoprotein MYC, which, in large quantities, causes self-destruction of the cancer cells. When this combination is enhanced ...
Feb 6, 2019
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The MDMX and MDM2 proteins play critical roles in keeping the tumor-suppressing protein p53 from damaging the production of healthy cells. But researchers have also found a causal connection between overexpression of MDMX ...
Jan 30, 2019
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Researchers at Kanazawa University report in Proceedings of the National Academy of Sciences (PNAS) that a particular signaling pathway in breast cancer tumors causes cancer cells to divide symmetrically, expanding the tumor. ...
Jan 25, 2019
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In an article recently published in JCI Insight, researchers from the University of Alabama at Birmingham and Vanderbilt University have identified checkpoint inhibitor resistance mechanisms in many solid tumor cancers, including ...
Jan 23, 2019
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Immunotherapies that take off the "brakes" on the adaptive anti-tumor response have worked well in melanoma and lung cancer but less so in breast cancers. That could change.
Jan 17, 2019
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As cancer cells respond to cues in their microenvironment, they can enter a highly plastic state in which they are susceptible to transdifferentiation into a different type of cell. Researchers at the University of Basel ...
Jan 14, 2019
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