The advent of small-molecule targeted therapies, a decade ago, revolutionized the treatment of metastatic melanoma, provided that the tumors carry the mutations to respond to these treatments. However, despite a remarkable ...
Sep 22, 2022
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DNA damage is one of the foundational causes of cancer. But researchers have now found that deliberately causing DNA damage—by delivering additional treatments like radiotherapy—could improve the effectiveness of immunotherapy ...
Sep 20, 2022
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Scientists at the UNC School of Medicine have made the surprising discovery that a molecule called EdU, which is commonly used in laboratory experiments to label DNA, is in fact recognized by human cells as DNA damage, triggering ...
Aug 23, 2022
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160
Proteins that are frequently altered in tumors play a prominent role in cancer research. The protein RFX7, a largely unknown transcription factor, has recently been linked to lymph node cancer. Researchers at the Leibniz ...
Jul 19, 2022
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Prostate cancers remain localized in the majority of cases, giving affected individuals a good chance of survival. However, about 20% of patients develop incurable metastatic prostate cancer, resulting in approximately 5,000 ...
Apr 4, 2022
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9
Hokkaido University scientists have identified new targets for treating an aggressive form of adult leukemia with existing drugs. The findings were published in the journal Blood.
Mar 31, 2022
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Researchers of the University of Barcelona and IDIBELL have found a mechanism that could explain the reappearance of tumors after clinical treatment. According to their research study, tumor cells are able to detect when ...
Dec 1, 2021
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Neuroendocrine cancer can manifest itself as many small tumors in a cluster in the small intestine. New research shows that, surprisingly, these tumors originate from different cells that have mutated independently. The finding ...
Nov 5, 2021
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48
In preclinical models, combining an investigational Aurora Kinase A (AURKA) inhibitor with a KRAS inhibitor or a WEE1 inhibitor showed efficacy against lung cancer cells with intrinsic or acquired resistance to KRAS inhibition, ...
Oct 7, 2021
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9
Growing blood vessels are experts at multitasking. Not only do cells in their walls divide, they must also sprout in new directions while learning to specialize, ultimately becoming part of vein, artery or lymphatic vessels. ...
Oct 5, 2021
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