A research team of 37 scientists, led by the Technical University of Munich, has developed a method to interrogate drug-induced post-translational modifications (PTMs) in a time and dose-dependent way.
The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category. Now, University of Michigan Rogel Cancer Center researchers have found success ...
Feb 15, 2023
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Tumor cells typically alter their energy metabolism and increase glucose uptake to support their rapid division and spread. This limits glucose availability for immune cells and therefore dampens the body's anti-cancer immune ...
Feb 14, 2023
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Before new drugs can be tested in animal experiments and later in clinical trials, they must undergo a large number of laboratory tests. This involves the use of so-called cell lines, i.e., human or animal cells of a specific ...
Feb 8, 2023
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In our body, we have both an innate immune system and an immune system that is developed throughout life. Part of the innate immune system consists of so-called NK cells. This is a type of immune cell that specializes in ...
Jan 20, 2023
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A new research paper titled "Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001" has been published in Oncotarget.
Jan 17, 2023
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A team of researchers from Michigan State University, Indiana University, The Ohio State University and Tulane University, has conducted a top-down proteomics study of isogenic human non-metastatic and metastatic colorectal ...
Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumors sensitive to a type of immunotherapy drug called a checkpoint inhibitor. This is according to ...
Dec 22, 2022
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Researchers from the University at Buffalo School of Pharmacy and Pharmaceutical Sciences recently published in Molecular & Cellular Proteomics, describing their work in identifying key metabolic regulators involved in cancer ...
Dec 13, 2022
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Colorectal cancer is one of the most common cancers. Its treatment is mainly based on chemotherapy. However, over time, chemotherapy induces resistance in the majority of patients, who end up being unresponsive to the drugs. ...
Oct 27, 2022
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