Neuroscience

Lipid epoxides target pain, inflammatory pathways in neurons

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, ...

Medications

Diagnosing intake of two new psychoactive substances

NUS pharmaceutical scientists have developed a systematic approach to understand how the human body manages two new psychoactive substances (NPS) by predicting their biological half-lives and measuring their biological activities ...

Neuroscience

Rethinking the link between cannabinoids and learning

Cannabinoids have a strong influence on how our brains work and how we behave. Many people are only aware of the recreational aspect of cannabinoids. But in fact these molecules naturally exist in our brains where they participate ...

Neuroscience

Cannabinoids decrease the metabolism of glucose in the brain

The nervous system comprises neurons and glial cells (glia means 'glue'). Astrocytes are the most abundant among the glial cells. Among many other functions they undertake to capture glucose from the blood stream to provide ...

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Cannabinoid

Cannabinoids are a class of chemical compounds which include the phytocannabinoids (oxygen-containing C21 aromatic hydrocarbon compounds found in the cannabis plant), and chemical compounds which mimic the actions of phytocannabinoids or have a similar structure (e.g. endocannabinoids, found in the nervous and immune systems of animals and that activate cannabinoid receptors). The most notable of the cannabinoids is ∆9-tetrahydrocannabinol (THC)—the primary psychoactive compound of cannabis.

Synthetic cannabinoids encompass a variety of distinct chemical classes: the classical cannabinoids structurally related to THC, the nonclassical cannabinoids including the aminoalkylindoles, 1,5-diarylpyrazoles, quinolines and arylsulphonamides, as well as eicosanoids related to the endocannabinoids.

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