Genetics
A natural history of neurons: Diverse mutations reveal lineage of brain cells
Walt Whitman's famous line, "I am large, I contain multitudes," has gained a new level of biological relevance.
Oct 1, 2015
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Page 17 - News tagged with cell mutations
Oncology & Cancer
Why some brain tumors respond to immunotherapy
Columbia researchers have learned why some glioblastomas—the most common type of brain cancer—respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy ...
Feb 15, 2019
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Oncology & Cancer
Researchers show that mutations in human livers can promote tissue regeneration
Researchers at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage.
Apr 4, 2019
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Oncology & Cancer
Study reveals first evidence inherited genetics can drive cancer's spread
Sometimes cancer stays put, but often it metastasizes, spreading to new locations in the body. It has long been suspected that genetic mutations arising inside tumor cells drive this potentially devastating turn of events.
May 25, 2020
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Psychology & Psychiatry
Survey of brain cell junctions shows striking similarities between schizophrenia and bipolar disorder
Although bipolar disorder and schizophrenia are diagnosed as distinct psychiatric conditions, both are considerably heritable with molecular roots that are poorly understood. Some people diagnosed with one disorder have symptoms ...
May 12, 2023
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Genetics
Study encourages cautious approach to CRISPR therapeutics
A comprehensive study—conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups—has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor ...
Nov 11, 2021
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Medical research
A 'weak spot' discovered that potentially makes multi-drug resistant tumors vulnerable
One of the greatest challenges facing cancer researchers is to understand why some patients don't respond to treatments. In some cases, tumors exhibit what is known as multidrug resistance (MDR), which significantly limits ...
Jul 22, 2022
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Genetics
How incurable mitochondrial diseases strike previously unaffected families
Researchers have shown for the first time how children can inherit a severe - potentially fatal - mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University ...
Jan 15, 2018
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Oncology & Cancer
New application of existing drug offers personalized therapy for lung cancer
Lung cancer remains the leading cause of cancer-related deaths worldwide. In contrast to other tumour types, lung tumours present a high number of genomic alterations—this is a consequence of exposure to carcinogenic substances ...
Dec 6, 2016
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Genetics
Molecular clocks control mutation rate in human cells
Every cell in the human body contains a copy of the human genome. Through the course of a lifetime all cells are thought to acquire mutations in their genomes. Some of the mutational processes generating these mutations do ...
Nov 9, 2015
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