Medical research
Researchers find accumulation of gene mutations in chronic graft-versus-host disease
Mutations in white blood cells can contribute to abnormal immune profile after hematopoietic stem cell transplantation.
May 7, 2020
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Page 35 - News tagged with cell mutations
Diabetes
Diabetes reversed in mice with genetically edited stem cells derived from patients
Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing ...
Apr 22, 2020
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Genetics
Finding genetic ripple effects in a single-cell environment
Although advances in genetics and genomics reveal numerous disease-associated gene mutations associated with disease, physicians and researchers still wrestle with the tricky challenge of linking those mutations to actual ...
Apr 22, 2020
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Oncology & Cancer
Human uterus colonized by clones with cancer-driving mutations that arise early in life
Many cells in the inner lining of the uterus carry 'cancer-driving' mutations that frequently arise early in life, report scientists from the Wellcome Sanger Institute, the University of Cambridge and their collaborators. ...
Apr 22, 2020
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Oncology & Cancer
Single cell division error triggers cascade of mutations that generate features of cancer
A team of researchers affiliated with multiple institutions in the U.S. and the U.K. has found that a single error during cell division can trigger a cascade of mutational events, generating many of the features found in ...
Genetics
Single mutation leads to big effects in autism-related gene
A new study in Neuron offers clues to why autism spectrum disorder (ASD) is more common in boys than in girls. National Institutes of Health scientists found that a single amino acid change in the NLGN4 gene, which has been ...
Apr 2, 2020
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Medical research
Researchers show that positive selection is major force shaping clonal hematopoiesis
A team of researchers from the University of Cambridge, Stanford University and Washington University School of Medicine has found evidence indicating that positive selection (as opposed to drift) is the major force shaping ...
Neuroscience
Scientists identify gene that first slows, then accelerates, progression of ALS in mice
Columbia scientists have provided new insights into how mutations in a gene called TBK1 cause amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that robs patients of movement, speech and ultimately, ...
Mar 27, 2020
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Oncology & Cancer
3-D genetic structure in blood cancer important beyond DNA code changes
Children with aggressive blood cancers have differences—not just in the DNA code of their blood cells—but also in the heavily twisted protein superstructure that controls access to genes.
Mar 23, 2020
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Genetics
Identified: 15 genes that trigger rapid growth of head and neck squamous cell carcinoma
A team of researchers affiliated with several institutions in Canada has identified 15 tumor suppressor genes that can trigger rapid growth of human head and neck squamous cell carcinoma (HNSCC) when they mutate. In their ...
