In addition to the four major bases in the DNA alphabet—A, C, G and T—there is also a minor "fifth" base, 5-methylcytosine (5mC), which plays a disproportionately important role in deciding whether genes and other DNA ...
Jul 29, 2019
0
117
Investigators at St. Jude Children's Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric ...
Jul 24, 2019
0
117
Each year, 9 months of dreams and anticipation shared by millions of parents-to-be turn to despair and fright when learning their child is born with a birth defect; an often-devastating event affecting one out of 20 children ...
Jul 24, 2019
0
473
A genetic mutation linked to dilated cardiomyopathy, a dangerous enlargement of the heart's main pumping chamber, activates a biological pathway normally turned off in healthy adult hearts, according to a study by researchers ...
Jul 17, 2019
0
49
A study by investigators from the Massachusetts General Hospital (MGH) Cancer Center has found that, contrary to common assumptions, the fact that a specific genetic mutation frequently arises in particular tumors may not ...
Jun 27, 2019
0
0
St. Jude Children's Research Hospital scientists have evidence that children with acute lymphoblastic leukemia mount a robust immune response to their cancer. The findings, which appear today in the journal Science Translational ...
Jun 26, 2019
0
0
Researchers have identified a genetic mutation that caused an 11-year-old girl to suffer a fatal reaction to infection with the Hepatitis A virus (HAV). The study, which will be published June 18 in the Journal of Experimental ...
Jun 18, 2019
0
43
Cell division is not perfect. As we get older, mutations often appear in genes in normal cells. Most of these mutated cells and their progeny—called "somatic clones"—have no effect on our health, but a tiny fraction can ...
Jun 6, 2019
0
180
Help for patients with sickle cell disease may soon come from gene editing to fix the mutation that causes the disease and boost the patient's own protective fetal hemoglobin.
Jun 3, 2019
0
48
For people diagnosed with advanced pancreatic cancer, the outlook is about as grim as it gets: the average patient won't live longer than a year.
Jun 3, 2019
1
289
