Using genetic engineering techniques, investigators at the Johns Hopkins Kimmel Cancer Center and its Ludwig Center, the Lustgarten Laboratory and Bloomberg~Kimmel Institute for Cancer Immunotherapy have designed a novel ...
Jul 10, 2024
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Acute lymphoblastic leukemia (ALL) is the most common cancer in children. This form of blood cancer, which also occurs in adults, is caused by malignantly degenerated precursor cells of certain white blood cells (B-cell precursors ...
Jul 1, 2024
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In studies with genetically engineered mice, Johns Hopkins Medicine researchers say they have identified a potentially new biological target involving Aplp1, a cell surface protein that drives the spread of Parkinson's disease-causing ...
Jun 17, 2024
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A team of Vanderbilt researchers has created a new series of drug candidates against a hard-to-target receptor involved in the formation of blood clots. The research, spearheaded by the labs of Jens Meiler, research professor ...
Jun 11, 2024
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Cleveland Clinic researchers have discovered a new location for a protein that helps ovarian cancer cells resist chemotherapy treatments and that fosters aggressive cancer stem cell growth.
Jun 10, 2024
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Johns Hopkins Medicine scientists say they have developed an artificial lymph node with the potential to treat cancer, according to a new study in mice and human cells. The newly developed lymph node—a sac filled with immune ...
Jun 6, 2024
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Researchers have developed an approach to "deleting" a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells. Writing in the journal Nature, the team reports ...
May 22, 2024
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Scientists have used breast cancer cells' weakness against themselves by linking a tumor-selective antibody with a cell-killing drug to destroy hard-to-treat tumors.
May 22, 2024
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A new paper by Dana-Farber Cancer Institute scientists lays the foundation for targeted therapies to inhibit the activation of nuclear factor kappa B (NF-κB), a transcription factor that plays a role in various autoimmune ...
Apr 25, 2024
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In a world-first, QIMR Berghofer scientists have discovered the mechanism that causes severe inflammation among millions of people with chronic liver disease.
Apr 12, 2024
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In biochemistry, a receptor is a protein molecule, embedded in either the plasma membrane or cytoplasm of a cell, to which a mobile signaling (or "signal") molecule may attach. A molecule which binds to a receptor is called a "ligand," and may be a peptide (such as a neurotransmitter), a hormone, a pharmaceutical drug, or a toxin, and when such binding occurs, the receptor undergoes a conformational change which ordinarily initiates a cellular response. However, some ligands merely block receptors without inducing any response (e.g. antagonists). Ligand-induced changes in receptors result in physiological changes which constitute the biological activity of the ligands.
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