Genetics

Scientists find cause of facial widening defects

Widening across the forehead and nose occurs when loss of cilia at the surface of the cells disrupts internal signaling and causes two GLI proteins to stop repressing midfacial growth. Ching-Fang Chang and Samantha Brugmann ...

Oncology & Cancer

Analysis of metastatic prostate cancers suggests treatment options

Cancer researchers have applied a comprehensive set of analytical tools to lethal cases of metastatic prostate cancer, yielding a detailed map of the complex networks of interactions among genes and proteins that enable prostate ...

Medical research

Stem cell study finds mechanism that controls skin and hair color

A pair of molecular signals controls skin and hair color in mice and humans—and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

Oncology & Cancer

How a metabolic pathway promotes breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...

Genetics

Scientists reveal endocardial origin of liver vasculature

On March 29, Nature Genetics published a research article titled "Genetic lineage tracing identifies endocardial origin of liver vasculature," from Prof. ZHOU Bin's lab at the Institute for Nutritional Sciences (INS), Shanghai ...

Oncology & Cancer

What can Frizzled7 reveal about breast cancer development?

A new study shows that Frizzled7 (FZD7), a protein present on human breast epithelial cells and a component of the Wnt signaling pathway is uniquely controlled by the Notch signaling pathway, both of which play key roles ...

Immunology

An alternative route to inflammation

Using a combination of newly developed methods, researchers led by Ludwig-Maximilians-Universitaet (LMU) in Munich immunologist Veit Hornung have defined a previously unknown pathway that triggers inflammation.

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