Genetics

Scientists find cause of facial widening defects

Widening across the forehead and nose occurs when loss of cilia at the surface of the cells disrupts internal signaling and causes two GLI proteins to stop repressing midfacial growth. Ching-Fang Chang and Samantha Brugmann ...

Oncology & Cancer

How a metabolic pathway promotes breast cancer metastasis

A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The ...

Genetics

Scientists reveal endocardial origin of liver vasculature

On March 29, Nature Genetics published a research article titled "Genetic lineage tracing identifies endocardial origin of liver vasculature," from Prof. ZHOU Bin's lab at the Institute for Nutritional Sciences (INS), Shanghai ...

Immunology

An alternative route to inflammation

Using a combination of newly developed methods, researchers led by Ludwig-Maximilians-Universitaet (LMU) in Munich immunologist Veit Hornung have defined a previously unknown pathway that triggers inflammation.

Immunology

How crystals precipitate cell death

Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now ...

Oncology & Cancer

Prostate cancer discovery may make it easier to kill cancer cells

A newly discovered connection between two common prostate cancer treatments may soon make prostate cancer cells easier to destroy. Drugs that could capitalize on the discovery are already in the pipeline, and a clinical trial ...

Oncology & Cancer

Signaling pathway suppresses brain tumors

Researchers at the University of Basel took a close look at a signaling pathway present in most organisms and found that it suppresses the formation of specific types of brain tumor. Their results have been published by the ...

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