A new study conducted by researchers at The Wistar Institute revealed how a key protein residing in the endoplasmic reticulum (ER) helps cells respond to stress. This process is especially important for B cells to respond ...
Mar 6, 2018
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In a new study, scientists at The Scripps Research Institute (TSRI) have identified drug candidates that can boost a cell's ability to catch the "typos" in protein production that can cause a deadly disease called amyloidosis.
Jul 20, 2016
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University of Cincinnati (UC) researchers have observed levels of HAX-1, an anti-cell death protein, drop significantly in mice after a heart attack and during heart failure resulting in cardiac cells dying at a higher than ...
Nov 16, 2015
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Chaperone proteins play an important role in protein folding in human cells and in bacteria and are promising new targets for drugs to treat cancer and Alzheimer's disease and for novel antiviral drugs and antibiotics. How ...
Mar 9, 2015
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Scientists at The Scripps Research Institute (TSRI) have identified a new cellular pathway that is affected in cystinosis, a rare genetic disorder that can result in eye and kidney damage.
Feb 10, 2015
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Scientists have discovered a previously unknown mechanism by which estrogen prepares cells to divide, grow and, in the case of estrogen-positive breast cancers, resist cancer drugs. The researchers say the work reveals new ...
Sep 29, 2014
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It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood. Neurodegenerative ...
May 29, 2014
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One of the hopes for victory against cancer hinges on naturally-occurring proteins whose job is to make their host cell die.
Feb 3, 2014
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(Medical Xpress)—The word "chaperone" refers to an adult who keeps teenagers from acting up at a dance or overnight trip. It also describes a type of protein that can guard the brain against its own troublemakers: misfolded ...
Jan 30, 2014
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Groundbreaking new findings by UC Irvine and German chemists about how cataracts form could be used to help prevent the world's leading cause of blindness, which currently affects nearly 20 million people worldwide.
Dec 5, 2013
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