In a paper published in NAR Cancer, researchers from the Center for Childhood Cancer Research at Nationwide Children's and their collaborators report a comprehensive 3D chromatin structural analysis and characterization of ...
Jun 14, 2023
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A single cell contains 2-3 meters of DNA, meaning that the only way to store it is to package it into tight coils. The solution is chromatin: a complex of DNA wrapped around proteins called histones. In the 3D space, this ...
Mar 15, 2023
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Many diseases affect how cells are spatially organized in tissues, such as in Alzheimer's disease, where amyloid-β proteins clump together to form plaques in the brain. Studying how cells differ in various regions of tissue ...
Dec 8, 2022
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In a study published in Cell Reports, Dr. Zhou Jiawei's Lab at the Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) of the Chinese Academy of Sciences, and Dr. Hu Gang's ...
May 19, 2021
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Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way—whole-genome profiling of open chromatin—to identify the kind of cell that leads to a given case of ...
Jul 11, 2016
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Cancer development is a complex process involving both genetic and epigenetic changes. Genetic changes in oncogenes and tumor-suppressor genes are generally considered as primary causes, since these genes may directly regulate ...
Apr 26, 2016
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DNA damage can lead to gene inactivation or deregulation and cause various diseases such as cancer; however, many DNA repair mechanisms allow cells to survive against such damage. A study lead by Antoine Simoneau of the laboratory ...
Jan 28, 2016
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A study led by researchers from Brigham and Women's Hospital suggests a new way to trace cancer back to its cell type of origin. By leveraging the epigenome maps produced by the Roadmap Epigenomics Program - a resource of ...
Feb 18, 2015
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A protein – already known to be involved in a cell's response to stress – called Tetratricopeptide repeat domain 5 (TTC5) is critical to the development of acute myeloid leukaemia (AML), according to a new Cancer Research ...
Apr 5, 2013
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A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early ...
Mar 14, 2012
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