A team of infectious and inflammatory disease specialists affiliated with several institutions in France reports that women are more susceptible to autoimmune diseases, such as lupus, due to failed X-chromosome inactivation.
Congenital heart disease (CHD) includes a variety of structural malformations affecting the heart and blood vessels. With growing understanding of the molecular processes involved in heart development, genetic variants have ...
May 16, 2024
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A study in mice suggests how chromosome inactivation may protect girls from a type of autism disorder inherited from their father's X chromosome.
Apr 30, 2024
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Scientists have unraveled the mechanisms of the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) signaling pathway activated by micronuclei, as well as its significant ...
Apr 9, 2024
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Researchers have been chipping away at the genetic causes of congenital heart disease (CHD) for a couple of decades. About 45% of cases of CHD have an identifiable cause, including chromosomal abnormalities, genetic variants ...
Apr 8, 2024
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University of Virginia School of Medicine researchers have discovered a gene on the Y chromosome that contributes to the greater incidence of heart failure in men. The work is published in the journal Nature Cardiovascular ...
Apr 1, 2024
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Researchers at the University of Colorado Anschutz Medical Campus and collaborators across the country have conducted the largest and most diverse study of men with extra X or Y chromosomes in the US using a large dataset ...
Mar 29, 2024
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A team of the University of Barcelona and the Biomedical Research Institute of Barcelona (IRB Barcelona) has designed a new bioinformatics tool to identify the chromosomal alterations that are characteristic of cancer cells.
Mar 21, 2024
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A cross-college collaboration is opening new doors in the study of male infertility by breaking down a key step in sperm formation. Isolating the intricacies of meiotic sex chromosome inactivation (MSCI), will now enable ...
Mar 12, 2024
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Daughters inherit two X chromosomes (one from the mother and one from the father), while sons inherent an X chromosome only from the mother. In new research published in Molecular Cell, investigators at Massachusetts General ...
Mar 11, 2024
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