Aging may be less about specific "aging genes" and more about how long a gene is. Many of the changes associated with aging could be occurring due to decreased expression of long genes, say researchers in an opinion piece ...
Mar 21, 2024
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A new study led by University of California, Irvine researchers has confirmed a link between altered DNA repair and increased DNA damage associated with spinocerebellar ataxia type 7 (SCA7), a debilitating, sometimes deadly ...
Nov 30, 2021
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An aggressive form of the childhood cancer neuroblastoma could be treatable with two cancer drugs currently used in the treatment of colon and ovarian cancer, a study led by researchers at The Institute of Cancer Research, ...
Sep 29, 2020
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Prostate cancer tumors harboring BRCA1/2 mutations are exceptionally sensitive to PARP inhibitors, while genomic alterations in other DNA damage response (DDR) genes are less responsive. To identify previously unknown genes ...
Apr 4, 2023
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Scientists at the IRCM and the University of Montreal discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children. The team, led by Frédéric Charron, PhD, found ...
Oct 14, 2014
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A protein abundantly found in treatment-resistant cancers holds an important tumor-suppressor out of the cell nucleus, where it would normally detect DNA damage and force defective cells to kill themselves, a team of scientists ...
Feb 27, 2012
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Many chemotherapeutics act by damaging the DNA. Since cancer cells divide more often than most normal cells, they are more sensitive to DNA-damaging agents. One exception are oocytes. To prevent birth defects, they initiate ...
Apr 18, 2018
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Researchers at the University of Illinois at Chicago College of Medicine have found that a molecule found at elevated levels in cancer cells seems to protect them from the "cell-suicide" that is usually triggered by chemotherapy ...
Mar 1, 2012
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(HealthDay)—Recurrent aphthous stomatitis is associated with increased total oxidative status and oxidative stress index values, according to a study published online Dec. 1 in the International Journal of Dermatology.
Dec 8, 2015
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A team of researchers led by Ludwig Chicago's Yang-Xin Fu and Ralph Weichselbaum has uncovered the primary signaling mechanisms and cellular interactions that drive immune responses against tumors treated with radiotherapy. ...
Nov 20, 2014
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