Many chemotherapeutics act by damaging the DNA. Since cancer cells divide more often than most normal cells, they are more sensitive to DNA-damaging agents. One exception are oocytes. To prevent birth defects, they initiate ...
Apr 18, 2018
0
6
Researchers from the Novo Nordisk Foundation Center for Protein Research have uncovered a new protein shield that aids in repairing damaged DNA in cells and affects resistance to drugs used for breast cancer treatment. The ...
Apr 16, 2018
0
6
An international team of researchers found how cancer cells respond to DNA damage signaling when in low oxygen, or hypoxia. Through comprehensive gene expression analyses, the team determined how one family of genes controls ...
Mar 20, 2018
0
7
Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research suggests. The ...
Mar 18, 2018
0
10
Mitochondria are cellular organelles with their own DNA. Their role in power generation makes them susceptible to oxidative damage, including the formation of DNA-damaging chemical complexes called adducts.
Feb 23, 2018
0
0
A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin 1 dysfunction in Alzheimer's ...
Feb 7, 2018
0
5
E-cigarettes are in the news again. This time with headlines that they may cause cancer.
Jan 31, 2018
0
19
University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment. The research team found that the protein RYBP prevents DNA repair in cancer cells, including breast cancer.
Jan 9, 2018
0
1
Neuroblastoma (NB) is the most common solid tumor found in children. It starts in some very early forms of nerve cells found in the embryo or fetus. Amplification of the gene MYCN is a well-characterized genetic alteration ...
Dec 29, 2017
0
12
Biophysicists have shown that following low-dose exposure to X-rays (at 80 milligrays), stem cells remain healthy, proliferate, and do not accumulate DNA damage to be passed on to their progeny. The paper was published in ...
Dec 20, 2017
0
102
