Diseases, Conditions, Syndromes

Scientists uncover mechanism behind development of viral infections

A team of researchers from the SingHealth Duke-NUS Academic Medicine Centre's Viral Research and Experimental Medicine Centre (ViREMiCS) found that immune cells undergoing stress and an altered metabolism are the reasons ...

Diseases, Conditions, Syndromes

Dengue infection: A shield against Zika-related birth defects

The Zika virus outbreak in Latin America less than 5 years ago had severe consequences for expectant mothers. Many who were infected with the Zika virus gave birth to children with microcephaly and other birth defects, collectively ...

Diseases, Conditions, Syndromes

Combating mosquito-borne diseases with bacteria

Viruses, spread through mosquito bites, cause human illnesses such as dengue fever, Zika and yellow fever. A new control technique harnesses a naturally occurring bacterium called Wolbachia that blocks replication of viruses ...

Diseases, Conditions, Syndromes

Breakthrough in predicting dengue fever outbreaks

Researchers have devised a method to forecast outbreaks of dengue—a sometimes fatal mosquito-borne disease—as much as four months in advance.

Medical research

Shedding light on the burden of dengue in Bangladesh

Dengue, also known as dengue fever, is a viral disease transmitted to humans by mosquitoes of the genus Aedes. The incidence of dengue is currently increasing dramatically, and it is now one of the diseases said to be re-emerging. ...

Diseases, Conditions, Syndromes

Early dengue virus infection could 'defuse' Zika virus

"We now know for sure that Zika virus infection during pregnancy can affect the unborn foetus in such a way that the child develops microcephaly and other severe symptoms," explains Prof Felix Drexler, a virologist at Charité ...

Diseases, Conditions, Syndromes

US approves dengue vaccine Dengvaxia

US health authorities have given their approval to dengue vaccine Dengvaxia, the controversial first treatment designed to protect against the deadly mosquito-borne virus.

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Dengue fever

Dengue fever (pronounced UK: /ˈdɛŋɡeɪ/, US: /ˈdɛŋɡiː/) and dengue hemorrhagic fever (DHF) are acute febrile diseases, found in the tropics, and caused by four closely related virus serotypes of the genus Flavivirus, family Flaviviridae. It is also known as breakbone fever. The geographical spread includes northern Australia, northern Argentina, and the entire Singapore, Malaysia, Taiwan, Thailand, Vietnam, Indonesia, Honduras, Costa Rica, Philippines, Pakistan, India, Sri Lanka, Bangladesh, Mexico, Suriname, Dominican Republic, Puerto Rico, Jamaica, Bolivia, Brazil, Guyana, Venezuela, Barbados, Trinidad and Samoa. Unlike malaria, dengue is just as prevalent in the urban districts of its range as in rural areas. Each serotype is sufficiently different that there is no cross-protection and epidemics caused by multiple serotypes (hyperendemicity) can occur. Dengue is transmitted to humans by the Aedes aegypti or more rarely the Aedes albopictus mosquito, which feed during the day.

The WHO says some 2.5 billion people, two fifths of the world's population, are now at risk from dengue and estimates that there may be 50 million cases of dengue infection worldwide every year. The disease is now epidemic in more than 100 countries.

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