Comprehensive sequencing program shows promise of precision medicine for advanced cancer
The average metastatic cancer has more genetic mutations than are seen in early stage tumors, a new study finds.
Aug 2, 2017
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The average metastatic cancer has more genetic mutations than are seen in early stage tumors, a new study finds.
Aug 2, 2017
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Cancer is mostly caused by changes in the DNA of our cells that occur over a lifetime rather than inherited traits. Identifying the causes of these mutations is a difficult challenge because many processes can result in a ...
Jul 28, 2017
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St. Jude Children's Research Hospital biologists have used engineered yeast cells to discover how a mutation that is frequently found in pediatric brain tumor high-grade glioma triggers a cascade of genomic malfunctions.
Jul 18, 2017
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Fanconi anemia is a rare genetic disease characterized by hematologic symptoms that include low platelet count and unusually large red blood cells. Mutations in nearly 20 genes have been identified as causative for Fanconi ...
Jul 10, 2017
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Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of cancer. As opposed ...
Jun 12, 2017
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A study published in Molecular Cancer Research reveals that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic ...
Jun 6, 2017
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Younger colon cancer patients appear to have more than three times as many mutations in their tumors as older patients, which could lead to more effective treatment decisions, say researchers at Georgetown Lombardi Comprehensive ...
May 17, 2017
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Scientists from the University of Bristol have looked at all 14,500 participants in Children of the 90s and found that if a girl's maternal grandmother smoked during pregnancy, the girl is 67% more likely to display certain ...
Apr 27, 2017
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Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres—the ends of our chromosomes. The study, published online in Nature Communications, explains how a group of genetic mutations ...
Apr 11, 2017
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In many parts of the world, including Southeast Asia and sub-Saharan Africa, exposure to a fungal product called aflatoxin is believed to cause up to 80 percent of liver cancer cases. This fungus is often found in corn, peanuts, ...
Mar 27, 2017
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