When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ravaged their ...
May 14, 2013
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Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited ...
Oct 14, 2020
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Alveolar rhabdomyosarcoma is a type of rare pediatric tumor. For more than 40 years there have not been any new developments regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now ...
Sep 19, 2022
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A new study by Claudia Kutter's research group at the Department of Microbiology, Tumor and Cell Biology (MTC) has identified potential pitfalls in the use of the gene editing technique CRISPR-Cas9, a gene scissors that is ...
Nov 21, 2023
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St. Michael's Hospital and King Saud University have received their first joint U.S. patent to use the BRCA1 gene as a therapy for cardiovascular disease.
Feb 10, 2012
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Researchers have identified three genes that play a pivotal role in the brain tumor choroid plexus carcinoma (CPC), a discovery that lays the groundwork for more effective treatment of this rare, often fatal cancer. St. Jude ...
May 11, 2015
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As an approach to personalized medicine, a new Nature Communications study proposes that "mutational footprints" of DNA repair are a promising predictive genetic marker for determining which tumors will respond to certain ...
May 26, 2022
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For women with Lynch syndrome, an association was found between the risk of endometrial cancer and the age of first menstrual cycle, having given birth, and hormonal contraceptive use, according to a study in the July 7 issue ...
Jul 7, 2015
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A DNA repair pathway-focused score has the potential to help determine if first-line platinum based chemotherapy can benefit advanced-stage ovarian cancer patients, according to a study published April 13 in the Journal of ...
Apr 13, 2012
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(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow the process, enhancing ...
May 22, 2013
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