Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.
Aug 15, 2016
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A laboratory study has revealed an entirely unexpected process for acquiring drug resistance that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1 or BRCA2 genes. The findings, ...
Jul 20, 2016
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Researchers at the University of Copenhagen have discovered a molecular mechanism that reads so-called epigenetic information and boosts repair of lesions in our DNA. This knowledge can be used to develop new targeted cancer ...
Jun 22, 2016
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Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer.
May 30, 2016
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Over the last several years, research teams across the world have scoured the genomes of cancer cells in a quest to uncover the genes that drive tumor growth. Meticulous analyses of the many thousands of genetic mutations ...
May 6, 2016
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(Medical Xpress)—The results of two studies by two different teams studying the role that DNA repair plays in the production of mutation-prone sequences—precursors to cancer, have been published in the journal Nature. ...
UNSW medical scientists have discovered that DNA repair is compromised at important regions of our genome, shedding new light on the human body's capacity to repair DNA damage.
Apr 13, 2016
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Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell—sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. Yet over the course of a ...
Apr 12, 2016
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In matters of the fundamental molecular biology of aging, we mammals are not so different from tiny C. elegans worms. Some of the biggest differences only serve to make them convenient research models. But one distinction ...
Feb 22, 2016
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Researchers have identified a molecular target and experimental treatment strategy for DNA repair defects behind Fanconi anemia - a complex genetic disorder responsible for birth anomalies, organ damage, anemia and cancer.
Jan 12, 2016
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