Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death. Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials
Aug 9, 2018
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In a recent paper published in Cell Reports, Saint Louis University researchers have uncovered new answers about why cells rapidly age in children with a rare and fatal disease. The data points to cellular replication stress ...
Mar 19, 2018
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A recent study by George Mason University researchers in the Department of Global and Community Health found that women who have given birth have shorter telomeres compared to women who have not given birth. Telomeres are ...
Mar 8, 2018
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In a new paper published in Nature Communications, a team led by Saint Louis University researcher Alessandro Vindigni, Ph.D. shares new information about how BRCA-deficient cancer cells operate, interact with chemotherapy ...
Nov 28, 2017
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Earlier this week, for the first time, a drug was FDA-approved for cancer based on disease genetics rather than type.
May 26, 2017
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A new study shows how errors in a specific gene can cause growth defects associated with a rare type of dwarfism.
Feb 13, 2017
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Cancer is a notoriously difficult disease to treat. Not only do a wide variety of cancers exist, requiring specialized treatments for each type, but cancer cells within an individual can morph and render previously potent ...
Oct 21, 2016
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Scientists at the University of Birmingham have described a previously-unknown molecular mechanism that could lead to the genetic mutations seen in certain types of aggressive cancer cells, involving a cell's own transcription ...
Oct 11, 2016
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DNA is replicated to pass genetic information to the daughter cells during cell proliferation. Replication errors, if not repaired, can lead to genetic mutations. For an individual organism, some DNA mutations may cause disease, ...
Aug 29, 2016
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A neurodevelopmental disorder for which there was no known cause has been linked to SON, a gene that is involved in essential mechanisms a cell uses to translate DNA into protein, as well as in DNA replication and cell division. ...
Aug 18, 2016
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